{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:27Z","timestamp":1745468727450,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We aimed to study the effect of cariporide (CP) on protecting the saphenous vein and the role of acetaldehyde dehydrogenase 2 (ALDH2) in coronary artery bypass grafting (CABG). &lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The saphenous vein is the main graft material used in CABG. Recent studies suggested that CP is effective in protecting against various cardiovascular diseases. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Segments of a surgically removed saphenous vein were used to examine the vascular response to CP. The ALDH2 genotype and expression of related proteins were assessed by Western blotting and immunohistochemistry. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among the conditions tested, the University of Wisconsin solution with CP (4\u00b0C, 5 min) treatment showed the best protective effect on the saphenous vein. The incidence of major adverse cardiac events was higher in the ALDH2-GA (heterozygous mutant) genotype population after CABG. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; CP plays a role in reducing the production of reactive oxygen species and apoptosis by ALDH2-mediated mitochondrial function improvement. The ALDH2 mutant genotype might be one of the risk factors for coronary atherosclerotic heart disease. <\/jats:p>","DOI":"10.1159\/000506071","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T22:00:34Z","timestamp":1582754434000},"page":"456-466","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Cariporide in Protecting Saphenous Vein among Different Aldehyde Dehydrogenase Genotypes"],"prefix":"10.1159","volume":"145","author":[{"given":"Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chentao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.06.049"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.10.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6260-6_5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314569"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5397-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-1289-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0456"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2014.10.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318223ebb2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000346128"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22818"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02736.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.07.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000356318"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707647"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6260-6_15"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.037"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2549-0"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:46:45Z","timestamp":1745423205000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,7]]},"published-print":{"date-parts":[[2020,7,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000506071","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2020]]}}}