{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:31Z","timestamp":1745468731588,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>A 74-year-old woman with Carney complex (CNC) and complaints of poor vision was found, on ophthalmic examination, to have a pigmented tumor involving the peripheral choroid and ciliary body in her right eye. The eye was enucleated and showed a ciliochoroidal melanoma with marked pleomorphism. The tumor did not recur or metastasize after almost 10 years of follow-up, and the patient died of unrelated causes. Molecular studies revealed a complex genome with multiple whole-chromosome losses including monosomy of chromosomes 1, 2 (including loss of &lt;i&gt;CNC2&lt;\/i&gt;at 2p16), 14, 17 (including loss of a copy of &lt;i&gt;PRAKA1&lt;\/i&gt; at 17q24.2), 18, 19, 21, 22, and X. No monosomy 3 was observed. This is only the second case of uveal melanoma in a patient with CNC, raising the possibility that this might represent a rare component of this syndrome. <\/jats:p>","DOI":"10.1159\/000506205","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T21:00:34Z","timestamp":1587502834000},"page":"311-317","source":"Crossref","is-referenced-by-count":3,"title":["Case Report with Review of the Literature: Uveal Melanoma in a Patient with Carney Complex \u2013 Another Rare Component of the Syndrome?"],"prefix":"10.1159","volume":"6","author":[{"given":"Diva\u00a0R.","family":"Salom\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane\u00a0M.","family":"Ida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia\u00a0T.","family":"Greipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u00a0Aidan","family":"Carney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198507000-00007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61843-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74112-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30279"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76773-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2001.101"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61989-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199003000-00002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199603000-00001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/79238"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.20.3037"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.4.268"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-20"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2017.07.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0209"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90027-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0532-RS"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.12.004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0685"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3159"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3052"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6614"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.09.008"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000152"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.10.039"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.03.005"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000645"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:48:09Z","timestamp":1745423289000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,10,1]]},"published-print":{"date-parts":[[2020,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000506205","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2020]]}}}