{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:23Z","timestamp":1747193423913,"version":"3.40.5"},"reference-count":23,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> We aimed to share our observations on the demographics, clinical characteristics, and outcomes of lymphonodular hyperplasia (LNH) in children. <b><i>Subjects and Methods:<\/i><\/b> The study included children on whom colonoscopy was performed between January 2015 and May 2018 (<i>n<\/i> = 361). Demographics, treatment modalities, and outcomes of the patients with LNH were recorded. <b><i>Results:<\/i><\/b> LNH was found in 66 patients (18.3%; mean age 8.6 \u00b1 5.96 years, 59.1% male). We found that the etiologic factors were food hypersensitivity (FH) in 25 (37.8%), nonspecific colitis in 12 (18.2%), irritable bowel syndrome in 10 (15.2%), familial Mediter\u00adranean fever in 7 (10.6%), primary immunodeficiency in 4 (6.1%), and intestinal dysmotility, oxyuriasis, Crohn\u2019s disease, and giardiasis in 1 (1.5%) patient. Additionally, in the genetic analysis of patients with idiopathic LNH (<i>n<\/i> = 4), we detected heterozygote <i>MEFV<\/i> mutations in all. Cow\u2019s milk and egg (25%) were the most common allergens in patients with FH. Symptoms of all patients (<i>n<\/i> = 25) improved after an elimination diet. <b><i>Conclusions:<\/i><\/b> LNH is a common finding in pediatric colonoscopies with a variety of etiologies ranging from FH and familial Mediterranean fever to immunodeficiency.<\/jats:p>","DOI":"10.1159\/000506257","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T22:00:33Z","timestamp":1580508033000},"page":"473-479","source":"Crossref","is-referenced-by-count":4,"title":["Ileocolonic Lymphonodular Hyperplasia in Children Related to Etiologies Ranging from Food Hypersensitivity to Familial Mediterranean Fever"],"prefix":"10.1159","volume":"29","author":[{"given":"Murat","family":"Cakir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Sag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Saygin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-932X","authenticated-orcid":false,"given":"Fazil","family":"Orhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600867735"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524054863924"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05062.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243936"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v6.i11.534"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.07.029"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02606.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.49.15"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.12.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a9083b"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/030097498440949"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i21.2211"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.345"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00084"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00312.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12328"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750056592"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.00090.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2018.21.4.271"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13396"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21040"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i46.10198"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(80)90047-4"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:48:29Z","timestamp":1745423309000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,4]]},"published-print":{"date-parts":[[2020,9,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000506257","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2020]]}}}