{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:18:53Z","timestamp":1783477133989,"version":"3.55.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objectives:<\/i><\/b> To explore trimester-specific thyroid function changes under different iodine statuses throughout pregnancy. <b><i>Methods:<\/i><\/b> A cross-sectional study was conducted to assess the pregnancy iodine status, and 2,378 healthy pregnant women covering all 3 trimesters were recruited. Urinary iodine concentration (UIC) was measured by collecting spot urine samples. Blood samples were collected to evaluate thyroid function. Thyroid B-ultrasonography was conducted to measure the thyroid volume (Tvol). <b><i>Results:<\/i><\/b> The median UIC was 168 \u03bcg\/L (111\u2013263 \u03bcg\/L). The UIC, free triiodothyronine (FT3), and free thyroxine (FT4) were significantly decreased as the pregnancy progressed (<i>p<\/i> &#x3c; 0.001, <i>p<\/i> for trend &#x3c;0.001), while Tvol increased (<i>p<\/i> &#x3c; 0.001, <i>p<\/i> for trend &#x3c;0.001). Thyrotropin (TSH) was significantly different between the 3 trimesters and showed an upward trend (<i>p<\/i> &#x3c; 0.001), but the <i>p<\/i> for trend was not significant (<i>p<\/i> for trend = 0.88). After stratification by UIC, there were no significant differences in serum TSH, FT4, or FT3 level between UIC groups. Tvol was significantly higher in the UIC \u2265500 \u03bcg\/L group in the first trimester (\u03b2: 2.41, 95% CI: 1.09\u20133.72, <i>p<\/i> &#x3c;0.001), as well as in the 250 \u2264 UIC &#x3c; 500 \u03bcg\/L group (\u03b2: 1.65, 95% CI: 0.61\u20132.70, <i>p<\/i> &#x3c; 0.001) and UIC \u2265500 \u03bcg\/L group (\u03b2: 3.35, 95% CI: 1.96\u20134.74, <i>p<\/i> &#x3c; 0.001) in the third trimester. <b><i>Conclusions:<\/i><\/b> No difference was observed in TSH, FT3, or FT4 among the different iodine status groups throughout pregnancy. Tvol increased as the pregnancy progressed, and it was especially higher in the UIC \u2265500 \u03bcg\/L group in the first and third trimesters. <\/jats:p>","DOI":"10.1159\/000506276","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T21:14:23Z","timestamp":1596057263000},"page":"165-174","source":"Crossref","is-referenced-by-count":8,"title":["Trimester-Specific Thyroid Function in Pregnant Women with Different Iodine 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