{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:17:23Z","timestamp":1788556643624,"version":"build-2803163510"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Initial treatment with the monoclonal anti-CD52 antibody alemtuzumab induces responses in the majority of patients with T-cell prolymphocytic leukemia (T-PLL). In eligible patients, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an option to consolidate hematological remissions. Here, we report our experience with 10 patients who received allo-HSCT against T-PLL. Notably, 3 patients with complete remission at transplantation and durable full-donor chimerism relapsed at months 12, 59, and 84 after transplantation, respectively. This relapse was associated with rapid progressive leukemia in 1 patient and extralymphatic lymphoma growth in the other 2. Despite CD52 positivity at relapse, alemtuzumab retreatment, donor lymphocyte infusions, and\/or chemotherapy including salvage therapy, allo-HSCT yielded a transient partial response, only. Alemtuzumab induction and consolidative allo-HSCT enabled prolonged disease-free survival in these patients but failed to procure cure.<\/jats:p>","DOI":"10.1159\/000506302","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T22:15:26Z","timestamp":1586297726000},"page":"105-110","source":"Crossref","is-referenced-by-count":11,"title":["Patterns of Late Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with T-Cell Prolymphocytic Leukemia"],"prefix":"10.1159","volume":"144","author":[{"given":"Evgenii","family":"Shumilov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Hasenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph\u00a0Johannes","family":"Szuszies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-5685","authenticated-orcid":false,"given":"Raphael","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald\u00a0Georg","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.12.3269.3269"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1385\/MO:23:1:17"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1141"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3920.3920_3920_3926"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00410-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22141"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22313"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13952"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000402"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1721"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.205"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372854"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.305"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12430"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.304"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx163"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0448-x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.252"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02688-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.5486.5486"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.404"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:05Z","timestamp":1745423345000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,25]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000506302","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12091173","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]}}}