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Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Since the incidence of mucosal melanoma is higher in the Japanese population compared to Caucasians, and since mucosal melanoma possesses a lower mutation burden compared to cutaneous melanoma, the efficacy of anti-PD1 antibody (Ab) monotherapy for mucosal melanoma is limited. Therefore, other targeting molecules that enhance the anti-tumor effects of immune checkpoint inhibitors are needed. In this report, we present a case with anti-PD1 Ab-resistant recurrent malignant melanoma of the nasal cavity successfully treated with nivolu\u00admab, ipilimumab plus denosumab combination therapy.<\/jats:p>","DOI":"10.1159\/000506327","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T22:00:33Z","timestamp":1585087233000},"page":"271-275","source":"Crossref","is-referenced-by-count":6,"title":["Successful Treatment of a Patient with anti-PD1 Antibody-Resistant Advanced Mucosal Melanoma with Nivolumab, Ipilimumab plus Denosumab Combination Therapy"],"prefix":"10.1159","volume":"13","author":[{"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Amagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yota","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Tanita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2110"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22071"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.9258"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0207-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.10.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14786"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1504030"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30126-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.248.37"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.06.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03207.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2015.1047584"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.10.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2018.1431088"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-17-0606"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.51.3572"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000504019"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:27Z","timestamp":1745423367000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000506327","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}