{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:48:45Z","timestamp":1768697325802,"version":"3.49.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction and Objective:<\/i><\/b> Neutrophil gelatinase-associated lipocalin (NGAL), a glycoprotein released by renal tubular cells, can be used as a marker of early tubular damage. We evaluated plasma NGAL level utilization for the identification of acute kidney injury (AKI) among ST-elevation myocardial infarction (STEMI) patients undergoing primary coronary intervention (PCI). <b><i>Methods:<\/i><\/b> 131 STEMI patients treated with PCI were prospectively included. Plasma NGAL levels were drawn prior to PCI (0 h) and 24 h afterwards. AKI was defined per KDIGO criteria of serum creatinine increase. Receiver-operating characteristic (ROC) methods were used to identify optimal sensitivity and specificity for the observed NGAL range. <b><i>Results:<\/i><\/b> Overall AKI incidence was 14%. NGAL levels were significantly higher for patients with AKI at both 0 h (164 \u00b1 42 vs. 95 \u00b1 30; <i>p<\/i> &#x3c; 0.001) and 24 h (142 \u00b1 41 vs. 93 \u00b1 36; <i>p<\/i> &#x3c; 0.001). Per ROC curve analysis, an optimal cutoff value of NGAL (&#x3e;120 ng\/mL) predicted AKI with 80% sensitivity and specificity (AUC 0.881, 95%, CI 0.801\u20130.961, <i>p<\/i> &#x3c; 0.001). In a multivariate logistic regression model, NGAL levels were independently associated with AKI at 0 h (OR 1.044, 95% CI 1.013\u20131.076; <i>p<\/i> = 0.005) and 24 h (OR 1.018, 95% CI 1.001\u20131.036; <i>p<\/i> = 0.04). <b><i>Conclusions:<\/i><\/b> Elevated NGAL levels, suggesting renal tubular damage, are independently associated with AKI in STEMI patients undergoing primary PCI.<\/jats:p>","DOI":"10.1159\/000506378","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T22:00:34Z","timestamp":1583964034000},"page":"154-161","source":"Crossref","is-referenced-by-count":8,"title":["Neutrophil Gelatinase-Associated Lipocalin for the Early Prediction of Acute Kidney Injury in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention"],"prefix":"10.1159","volume":"10","author":[{"given":"Ilan","family":"Merdler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren-Lee","family":"Rozenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zahler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Shtark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Goldiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-5490","authenticated-orcid":false,"given":"Itamar\u00a0Shimon","family":"Loewenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Fortis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviram","family":"Hochstadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gad","family":"Keren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacov","family":"Shacham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b9eb3b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0680-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002729"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05150512"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.07.020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000368474"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/189797"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2018.1487860"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2015.1123354"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.01.037"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0461-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.9.987"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90873-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2018.11.006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016028"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030261"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007080901"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.01.123"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.917070"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081702"}],"container-title":["Cardiorenal 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