{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:38Z","timestamp":1745468738348,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To report the case of a patient with adrenocorticotropic hormone (ACTH)-producing pituitary adenoma who developed a mental disorder after initial surgery that kept him from undergoing scheduled follow-up visits and who ultimately had a giant recurrent tumor that resulted in blindness. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; A 37-year-old male presented with the primary complaint of decreased visual acuity (VA) in both eyes and visual field defects. Visual field examination revealed bitemporal hemianopia. Magnetic resonance imaging (MRI) showed a pituitary tumor of approximately 4 cm in diameter extending from the intrasellar region to the sphenoid sinus and the suprasellar region. Transnasal transsphenoidal surgery was performed. Immunostaining of tumor tissue collected intraoperatively showed ACTH-positive cells, thus leading to the diagnosis of ACTH-producing pituitary adenoma. Postoperatively, the patient reportedly developed mental disorder that possibly interfered with scheduled appointments or continuous follow-up visits for many years, so we had no postoperative data about the vision\/visual filed. Seven years later, he presented with markedly decreased VA (i.e., no light perception) in both eyes. Fundus examination showed bilateral marked optic disc atrophy. MRI showed a larger than 8-cm diameter giant recurrent pituitary adenoma in the suprasellar region, for which craniotomy was performed for partial tumor resection. Preoperatively, his blood cortisol level was low, and the lesion was deemed a nonfunctioning pituitary adenoma. Postoperatively, no significant complications occurred, yet his VA was no light perception OD and light perception OS. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Clinicians should be aware that patients with ACTH-producing pituitary adenomas may develop a mental disorder following surgery and possibly be unable to undergo scheduled follow-up, thus illustrating the importance of establishing an adequate patient follow-up system.<\/jats:p>","DOI":"10.1159\/000506392","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T22:00:39Z","timestamp":1583359239000},"page":"92-99","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Giant Pituitary Adenoma Associated with a Postoperative Mental Disorder That Ultimately Resulted in Bilateral Blindness"],"prefix":"10.1159","volume":"11","author":[{"given":"Masahiro","family":"Tonari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Oku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sugasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naokado","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kurisu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunehiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139088"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2010.48.3.213"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.01.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-009-0595-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-009-0551-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000134287.19377.A2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050619"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80885-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.8690878.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2893"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0347-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255459.14764.BA"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000298504"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2015.04.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383856"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.JNS152709"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:50:23Z","timestamp":1745423423000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000506392","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2020,3,4]]}}}