{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:35:01Z","timestamp":1784550901511,"version":"3.55.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> The aim of this study was to assess the biocompatibility of several intra-tympanic (IT) drug delivery vehicles and to compare hearing outcomes. <b><i>Materials and Methods:<\/i><\/b> After acute acoustic trauma, rats were treated with IT 10 mg\/mL dexamethasone phosphate (D) and divided into the following groups for drug delivery: saline + D (<i>n<\/i> = 15), hyaluronic acid (HA) + D (<i>n<\/i> = 17), and methoxy polyethylene glycol-<i>b<\/i>-polycaprolactone block copolymer (MP) + D (<i>n<\/i> = 24). <b><i>Results:<\/i><\/b> No inflammation was found in the saline + D or HA + D groups. The duration of vehicle\/drug persistence in the bulla was significantly longer for the MP + D (47.5 days) and HA + D groups (1.8 days) than for the saline + D group (&#x3c;1 day). The tympanic membrane was significantly thicker in the MP + D group than in the saline + D and HA + D groups. The proportion of ears with good hearing outcome was significantly higher (63.6%) in the HA + D group than in the MP + D group. The number of hair cells in the hearing loss (HL) control group was significantly lower than in the MP + D group. <b><i>Discussion\/Conclusion:<\/i><\/b> HA shows great potential as a biocompatible vehicle for D delivery via the IT route, without an inflammatory reaction and with better hearing outcomes. Considering inflammation and hearing, MP may not be a good candidate for IT drug delivery. <\/jats:p>","DOI":"10.1159\/000506535","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T21:01:31Z","timestamp":1589403691000},"page":"291-296","source":"Crossref","is-referenced-by-count":11,"title":["Biocompatibility and Therapeutic Effect of 3 Intra-Tympanic Drug Delivery Vehicles in Acute Acoustic Trauma"],"prefix":"10.1159","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-5134","authenticated-orcid":false,"given":"Mina","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Soo","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Wook","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u00a0Hun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u00a0Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Whan","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-4108-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102841"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000313506"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102834"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.052"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909107393"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818599d5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/pen.20581"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.01.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181c351f2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38937"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.066"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-REC-10-12-04"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2007.07.012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000345208"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:25Z","timestamp":1745423485000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2020,11,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000506535","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12293159","asserted-by":"subject"}]},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}