{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:30:35Z","timestamp":1768401035807,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> Systemic administration of magnesium sulfate (MgSO<sub>4<\/sub>) has been proposed as a treatment for pediatric patients with acute asthma. However, previous trials show mixed results and uncertain evidence of benefit. The aim of the study was to ascertain whether intravenous (IV) MgSO<sub>4<\/sub> improves lung function parameters in children with acute asthma. <b><i>Methods:<\/i><\/b> This was a prospective clinical trial. All patients with acute asthma received 40\u201350 mg\/kg or maximum 1,500 mg (&#x3e;30 kg) of single dose IV MgSO<sub>4<\/sub>, administered over 60 min. Spirometry was conducted before and 15 min after MgSO<sub>4<\/sub> infusion. <b><i>Results:<\/i><\/b> One hundred and fifteen children aged 6 to 17 years presenting with acute asthma and FEV<sub>1<\/sub> between 40% and 75% of predicted were included. Then, the patients were classified into 2 groups; mild asthma attack (FEV<sub>1<\/sub> ranged from 60% to 75%; <i>n<\/i> = 50) or moderate asthma attack (FEV<sub>1<\/sub> ranged from 40% to 59%; <i>n<\/i> = 65). The baseline characteristics were similar in both groups. The mean percent predicted pre and post values for FEV<sub>1<\/sub>\/FVC ratio (mild group: 82.59 \u00b1 9.46 vs. 85.06 \u00b1 8.95; moderate group: 77.31 \u00b1 11.17 vs. 79.99 \u00b1 11.77), FEV<sub>1<\/sub> (mild group: 67.14 \u00b1 4.99 vs. 72.29 \u00b1 8.05; moderate group: 48.50 \u00b1 6.81 vs. 53.78 \u00b1 9.81), PEF (mild group: 65.49 \u00b1 12.32 vs. 71.37 \u00b1 12.96; moderate group: 47.56 \u00b1 11.78 vs. 51.97 \u00b1 13.98), and FEF<sub>25\u201375<\/sub> (mild group: 58.20 \u00b1 12.24 vs. 66.57 \u00b1 16.95; moderate group: 37.77 \u00b1 11.37 vs. 43.41 \u00b1 14.19) showed a statistically significant (<i>p<\/i> &#x3c; 0.05 for all) bronchodilator effect after MgSO<sub>4<\/sub> infusion in both groups with few side effects. <b><i>Conclusion:<\/i><\/b> Administration of IV MgSO<sub>4<\/sub> was associated with improved pulmonary function in children with acute asthma. <\/jats:p>","DOI":"10.1159\/000506595","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T22:00:57Z","timestamp":1582149657000},"page":"292-298","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of Magnesium Sulfate Treatment in Children with Acute Asthma"],"prefix":"10.1159","volume":"29","author":[{"given":"Ali","family":"\u00d6zdemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-7277","authenticated-orcid":false,"given":"Dilek","family":"Do\u011fruel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00234"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-032304048-8.50063-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-8.1.40"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2165-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3310\/hta18220"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.2.489"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70023-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.10.979"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-199909000-00005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70037-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2017.06.002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.050005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000909"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12780"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.04.029"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.86.6.868"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:52Z","timestamp":1745423512000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,5,29]]},"published-print":{"date-parts":[[2020,6,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000506595","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}