{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:28:37Z","timestamp":1789097317065,"version":"build-2803163510"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> The incidence of non-alcoholic fatty liver disease (NAFLD) in children increased rapidly. However, the pathogenesis of NAFLD, especially how non-alcoholic fatty liver progress to non-alcoholic steatohepatitis, is still unclear. This study aims to explore the exosomal miRNAs profiles and the underline pathogenesis of child NAFLD. <b><i>Methods:<\/i><\/b> Twenty NAFLD and 20 health control were enrolled in this study. Circulating exosomes were isolated, and RNA sequencing was performed in test set (3 NAFLD\/3 Controls). The differentially expressed miRNAs (DEM) were further validated in validation set (17 NAFLD\/17 Controls). Spearman correlation \u00adanalysis was used to investigate the association between DEM and clinical parameters. <b><i>Results:<\/i><\/b> Eighty-two miRNAs were differentially expressed (absolute fold change &#x3e;2 and <i>p<\/i> &#x3c; 0.05) in the 2 groups, they were involved in fat acid metabolism, starch and sucrose metabolism, bile acid metabolism and inflammation. miRNA122-5p, miRNA34a-5p, \u00admiRNA155-5p and miRNA146b-3p were up-regulated in NAFLD group (<i>p<\/i> &#x3c; 0.05) and positively correlated with body mass index (<i>r<\/i>, 0.41\u20130.59), alanine aminotransferase (<i>r<\/i>, 0.36\u20130.52), aspartate transaminase (<i>r<\/i>, 0.31\u20130.48) and uric acid (UA, <i>r<\/i>, 0.51\u20130.69; <i>p<\/i> &#x3c; 0.05). <b><i>Conclusions:<\/i><\/b> Circulating exosomal miRNAs may be involved in the pathogenesis of NAFLD and correlated with transaminase and UA.<\/jats:p>","DOI":"10.1159\/000506665","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T22:00:44Z","timestamp":1584136844000},"page":"44-53","source":"Crossref","is-referenced-by-count":16,"title":["Exosomal miRNAs Profile in Children\u2019s Nonalcoholic Fatty Liver Disease and the Correlation with Transaminase and Uric Acid"],"prefix":"10.1159","volume":"76","author":[{"given":"Xuelian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,3,13]]},"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:52:29Z","timestamp":1745423549000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,4,30]]},"published-print":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000506665","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}