{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:45:15Z","timestamp":1790603115084,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Platinum\/S-1 (PS) and platinum\/5-fluorouracil (PF) as first-line chemotherapies are extensively used for the treatment of advanced gastric or gastroesophageal junction cancer (AGC); however, there is no definite consensus on which regimen is best. In our meta-analysis, we compared PS with PF in terms of their efficacy and safety in AGC patients. <b><i>Methods:<\/i><\/b> PubMed, ScienceDirect, Web of Science, Scopus, Ovid MEDLINE, EMBASE, The Cochrane Library, Google Scholar, and CNKI were systematically searched for pertinent literature. We analyzed overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse effects (AEs) as major end points. <b><i>Results:<\/i><\/b> A total of 3,225 studies were identified, among which 6 randomized controlled trials, including 1,736 participants, were ultimately included in our analysis. Our results showed that PS and PF were comparable in terms of OS (<i>p<\/i> = 0.33, 95% confidence interval [CI]: 0.84\u20131.06), PFS (<i>p<\/i> = 0.63, 95% CI: 0.87\u20131.09), ORR (<i>p<\/i> = 0.38, 95% CI: 0.91\u20131.28), DCR (<i>p<\/i> = 0.41, 95% CI: 0.86\u20131.43), total AEs (<i>p<\/i> = 0.41, 95% CI: 0.98\u20131.01), and grade \u22653 AEs (<i>p<\/i> = 0.58, 95% CI: 0.82\u20131.41). However, those who received PF had a shorter time to failure (TTF) (<i>p<\/i> = 0.01, 95% CI: 0.77\u20130.97), and a significantly higher rate and more severe cases of stomatitis, nausea, and hypokalemia were reported in the PF group. <b><i>Conclusions:<\/i><\/b> PF and PS show similar antitumor efficacy (OS, PFS, ORR, and DCR), but patients receiving PS exhibit longer TTF and fewer AEs (stomatitis, nausea, and hypokalemia) than those receiving PF. <\/jats:p>","DOI":"10.1159\/000506671","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T21:00:27Z","timestamp":1591995627000},"page":"11-20","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Platinum\/S-1 and Platinum\/5-Fluorouracil as First-Line Chemotherapy for Advanced Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis Based on Randomized Controlled Trials"],"prefix":"10.1159","volume":"65","author":[{"given":"Dongyi","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21314"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108940"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1039\/c0dt00292e"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4706"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.07.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5959"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx275"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv316"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12465"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-014-9680-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-017-0753-2"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:52:35Z","timestamp":1745423555000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":13,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2020,9,17]]},"published-print":{"date-parts":[[2020,9,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000506671","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12471572","asserted-by":"subject"}]},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}