{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:58:40Z","timestamp":1760551120824,"version":"3.40.5"},"reference-count":36,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>In this review, human methotrexate dosing regimens, as well as their relationship to data from in vitro cell culture and in vivo animal and human studies, are discussed. Low-dose, intermediate-dose, and high-dose therapies are covered. Since in vitro and in vivo screenings of potential cancer drugs are commonplace in the development of cancer chemotherapy, comparisons of the three criteria for effectiveness are important. <\/jats:p>","DOI":"10.1159\/000506705","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T21:04:05Z","timestamp":1588712645000},"page":"520-527","source":"Crossref","is-referenced-by-count":7,"title":["Dose Issues in Cancer Chemotherapy"],"prefix":"10.1159","volume":"98","author":[{"given":"Syed A.A.","family":"Rizvi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-2954","authenticated-orcid":false,"given":"Yasser","family":"Shahzad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman M.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawshad","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1021\/la0503451"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/230949900701500113"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283375d5c"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1936"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197504172921607"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.3.1.1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(89)90134-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11797"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9621"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s1382-6689(00)00041-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.02.038"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A052"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1589"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950040305"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-102525"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809058397"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0212-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.061150"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2005.02.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s1054-3589(08)60009-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.10"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.42"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.8.570"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1979.143"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.011"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nm0698-655"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(94)92399-x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.1.2442794"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/bf00689280"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916060-00001"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006497202341"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/bf00686036"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(98)00191-8"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328349c524"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1211"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:52:55Z","timestamp":1745423575000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,5]]},"published-print":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000506705","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2020]]}}}