{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:58:42Z","timestamp":1781661522059,"version":"3.54.5"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Ectopic hepatocellular carcinoma (HCC) is a rare malignancy, which manifests similar morphology and immunohistochemistry to intrahepatic HCC. Herein, we report a case of ectopic HCC in a 73-year-old male. The patient presented to our hospital with gradually progressing right lower abdominal pain, and enhanced computed tomography revealed multiple nodules in the peritoneum without intrahepatic mass. A diagnostic laparoscopy was performed, and the final pathology result confirmed that it was HCC. Additional laboratory tests showed elevated serum alpha-fetoprotein and protein induced by vitamin K absence-II (PIVKA-II) levels, suggesting our diagnosis. The patient received sorafenib, a tyrosine kinase inhibitor (TKI), for unresectable ectopic HCC. However, the tumor progressed, and because of tarry stools and hemorrhagic anemia, sorafenib was ceased after 7 months of therapy. One month after the cessation of sorafenib, the PIVKA-II level increased abruptly, and the patient died 1 year after diagnosis. The effective treatment for unresectable ectopic HCC is still unknown. Additional cases should be accumulated to determine the effect of TKI on ectopic HCC. <\/jats:p>","DOI":"10.1159\/000506929","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T21:00:53Z","timestamp":1588021253000},"page":"226-233","source":"Crossref","is-referenced-by-count":7,"title":["Unresectable Ectopic Hepatocellular Carcinoma Treated with Sorafenib"],"prefix":"10.1159","volume":"14","author":[{"given":"Yi-Ling","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miyayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotaro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-6545","authenticated-orcid":false,"given":"Keiji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Morihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-4407","authenticated-orcid":false,"given":"Yasuaki","family":"Takeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shakado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Sakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihito","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9329-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2017.72403"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000441020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290144"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000314042"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i31.4270"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000343433"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006747"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082014000200015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000131037.92864.df"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2017.1336538"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146456"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2590-9"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/506929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:41Z","timestamp":1745423741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000506929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,5,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000506929","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]}}}