{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:10Z","timestamp":1787017930742,"version":"build-2736575974"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Ischaemic colitis (IC) is the most frequent form of ischaemia of the digestive tract. Due to the worldwide increasing use of medications, there is a growing interest in drug-induced IC. This study reports a rare case of IC directly due to amoxicillin-clavulanate intake. The objective of the study was to describe the evolution of this novel manifestation. An 18-year-old man, non-smoker, with an insignificant medical history, presented with diarrhoea and cramping abdominal pain that started the day following the end of a 10-day amoxicillin-clavulanate course for recent upper respiratory tract infection. Stool cultures including &lt;i&gt;Clostridium difficile&lt;\/i&gt; toxin testing were negative. Colonoscopy documented an erosive-ulcerative colitis of the sigmoid and the descending colon. Histological examination of the colon biopsies revealed an IC with focal pseudomembranous areas in the descending-sigmoid colon. Thrombophilia screening tests were negative. The patient was discharged from the hospital without symptoms, and another colonoscopy was performed 3 weeks after the previous one, which documented normal endoscopic and histological findings. Amoxicillin-clavulanate IC is a very rare condition and should be suspected once infectious diseases, vascular\/haemodynamic causes and a prothrombotic\/hypercoagulable state have been excluded. Immediate discontinuation of the antibiotic leads to rapid disease remission.<\/jats:p>","DOI":"10.1159\/000507014","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T17:05:15Z","timestamp":1588179915000},"page":"242-247","source":"Crossref","is-referenced-by-count":7,"title":["Amoxicillin-Clavulanate-Induced Ischaemic Colitis"],"prefix":"10.1159","volume":"14","author":[{"given":"Marco","family":"Alonge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Benini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Cannatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Missale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-6600","authenticated-orcid":false,"given":"Chiara","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.061"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.5.384"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048275"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000145399.35851.10"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01260.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.011452"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.140848"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300406"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.525794"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:56:55Z","timestamp":1745409415000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,5,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000507014","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]}}}