{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:45:09Z","timestamp":1784868309549,"version":"3.55.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) is a chronic progressive myelopathy associated with an inflammation of the central nervous system (CNS), being characterized by perivascular infiltration of inflammatory cells. HTLV-1-infected cells have the capacity to migrate through endothelial layers by enhancing adhesion receptor expression and corresponding ligands. T cells interact with the extracellular matrix via integrin receptors and these interactions affect both cell migration and proliferation. The importance of these interactions in retrovirus-induced diseases, however, remains less clear. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Herein we studied the expression of 3 integrin alpha chains (CD49d, CD49e, and CD49f) on the membrane of T-cell subsets in patients infected by HTLV-1, both HAM\/TSP patients and oligo\/asymptomatic subjects who were asymptomatic or presented slight manifestations related to the virus infection. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We observed higher peripheral blood frequency of CD49d&lt;sup&gt;hi&lt;\/sup&gt;CD4&lt;sup&gt;+&lt;\/sup&gt; and CD49d&lt;sup&gt;hi&lt;\/sup&gt;CD8&lt;sup&gt;+&lt;\/sup&gt; T cells in HTLV-1-infected patients. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our findings suggest that the increased expression of adhesion molecules, such as CD49d on T lymphocytes from HTLV-1-infected patients may contribute to the pathogenesis of the disease, in both oligo\/asymptomatic and HAM\/TSP-infected subjects. Accordingly, it is conceivable that there is a potential use of CD49d as target for a therapeutic approach aiming at blocking migration of activated T cells from HTLV-1-infected patients into the CNS, thus avoiding the progression to HAM\/TSP. <\/jats:p>","DOI":"10.1159\/000507086","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T21:01:32Z","timestamp":1596661292000},"page":"113-122","source":"Crossref","is-referenced-by-count":7,"title":["CD49d Is Upregulated in Circulating T Lymphocytes from HTLV-1-Infected Patients"],"prefix":"10.1159","volume":"27","author":[{"given":"L.T.\u00a0Ara\u00fajo","family":"Janah\u00fa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos\u00a0Araujo","family":"Da\u00a0Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio\u00a0Carlos\u00a0Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara\u00a0Brasil","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ribeiro-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna\u00a0Reis","family":"Santos-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaize\u00a0Quiroga","family":"Chometon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro\u00a0Luis","family":"Bertho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda\u00a0Maria","family":"Da-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Gomes-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(99)00173-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0143"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/v10010001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-209619"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0437-2015"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/508177"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086\/432058"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086\/341251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097685"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/13550280260422668"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.22.931"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21111"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00398"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/v8010005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.13.6021-6030.2000"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000205"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4161\/viru.19697"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00539-16"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1580"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00158-12"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7591"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90299-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(97)80065-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.35.195"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666161222141318"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2003.00235.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0066-2"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4149\/av_2015_03_247"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/v8030074"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000139130"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080115"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7374-3_16"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.09.009"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/356063a0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.09.012"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24481"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:57:31Z","timestamp":1745423851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,29]]},"published-print":{"date-parts":[[2021,2,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000507086","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12765272","asserted-by":"subject"}]},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}