{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:31:13Z","timestamp":1747193473988,"version":"3.40.5"},"reference-count":9,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Previous studies have demonstrated synergy between piperacillin (PIP)-tazobactam (TAZ) (TZP) and vancomycin (VAN) against methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; (MRSA). However, it is unknown whether PIP and\/or TAZ synergizes with VAN against MRSA. We sought to determine whether PIP and\/or TAZ synergizes with VAN against MRSA in vitro. The activity of PIP and\/or TAZ with and without VAN (1\/2 the minimum inhibitory concentration) was tested against 5 clinical MRSA isolates using a 24-h time-kill methodology. Antibiotic susceptibilities, accessory gene regulator (&lt;i&gt;agr&lt;\/i&gt;) operon functionality, and US strain type were also determined for the isolates. The combination of VAN and TZP was bactericidal against 3\/5 isolates and synergistic against 4\/5 isolates tested. Neither PIP nor TAZ alone combined with VAN demonstrated a significant reduction in bacterial growth. The combination of TZP and VAN was less active against the lone isolate with &lt;i&gt;agr&lt;\/i&gt; dysfunction. In summation, the combination of VAN with both PIP and TAZ was required for synergy against MRSA. This antibiotic combination may not be effective against unique MRSA strain types. <\/jats:p>","DOI":"10.1159\/000507241","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T21:00:25Z","timestamp":1589317225000},"page":"233-237","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Role of Piperacillin and Tazobactam in Combination with Vancomycin against Methicillin-Resistant &lt;b&gt;&lt;i&gt;Staphylococcus aureus&lt;\/i&gt;&lt;\/b&gt;"],"prefix":"10.1159","volume":"64","author":[{"given":"Thomas J.","family":"Dilworth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-2255","authenticated-orcid":false,"given":"Haedi","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e-Claude","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1396906"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01888-13"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.06.027"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01564-16"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1892-1895.2006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00594-13"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki243"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01745-16"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2013.10.002"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:58:27Z","timestamp":1745423907000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":9,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2020,7,7]]},"published-print":{"date-parts":[[2020,7,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000507241","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2019]]}}}