{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:25:52Z","timestamp":1768443952098,"version":"3.49.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Primary synovial sarcoma (SS) of the thyroid (PSST) is extremely rare. Its differential diagnosis from other neoplasms is essential since it has different management protocols and prognosis. &lt;b&gt;&lt;i&gt;Case:&lt;\/i&gt;&lt;\/b&gt; A 26-year-old man with a 4.5-cm solid lobulated mass was seen at an outside hospital. Fine needle aspiration (FNA) was interpreted as a papillary carcinoma, and a total thyroidectomy was performed. The final histologic diagnosis was spindle epithelial tumor with thymus-like differentiation (SETTLE). No metastases were detected at that time, and the patient received radioactive iodine treatment. Two years post-surgery, he was seen at our hospital with a local recurrence, and FNA was considered as consistent with SETTLE. The mass was resected, and a left modified radical neck dissection was performed. The tumor revealed necrosis and a high mitotic index. Following histologic, immunohistochemical, and molecular studies, the tumor was classified as a PSST. The patient received chemotherapy and targeted immunotherapy, but he died 41 months after the initial presentation. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The main diagnostic pitfall of PSST is SETTLE. The presence of mitotic figures and basal lamina material, negative staining for smooth muscle actin, and positive staining for transducer-like enhancer of split 1 antibody favor SS over SETTLE. &lt;i&gt;SYT&lt;\/i&gt; gene rearrangement is essential to establish the definitive diagnosis of PSST. <\/jats:p>","DOI":"10.1159\/000507312","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T21:00:33Z","timestamp":1590526833000},"page":"498-506","source":"Crossref","is-referenced-by-count":7,"title":["Primary Synovial Sarcoma of the Thyroid: Challenges in Cytologic Diagnosis and Review of the Literature"],"prefix":"10.1159","volume":"64","author":[{"given":"Dilaver","family":"Demirel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"Erkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suna","family":"Erk\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem","family":"Narl\u0131 Iss\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Ramzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.S.S154"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2011.4.4.204"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000357913"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.670"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13113"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20564"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23605"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23327"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.70736"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP45SSNAOPXYXU"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.47"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31819e61c8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0716-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.29"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPB7PS6QHWEFRK"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-011-9172-9"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:59:17Z","timestamp":1745423957000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2020,9,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000507312","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}