{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:10:19Z","timestamp":1781629819496,"version":"3.54.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Purpose:<\/i><\/b> The aim of this study was to investigate the influence of androgen deprivation therapy (ADT) on the progression of non-alcoholic fatty liver disease (NAFLD) in patients with prostate cancer (PCa) by evaluation of hepatic steatosis on computed tomography (CT). <b><i>Methods:<\/i><\/b> The study included 77 PCa patients who underwent abdominal CT at baseline and after 6 months of ADT. The degree of hepatic steatosis was evaluated according to the attenuation value for liver parenchyma (CT<sub>LP<\/sub>), the attenuation ratio for liver and spleen (LS<sub>ratio<\/sub>), and the difference in attenuation between LS (LS<sub>dif<\/sub>). The associations between these 3 indices and various metabolic syndrome-related factors were analyzed. <b><i>Results:<\/i><\/b> The number of NAFLD patients increased from 9 (11.6%) at baseline to 16 (20.7%) after ADT. The CT<sub>LP<\/sub>, LS<sub>ratio<\/sub>, and LS<sub>dif<\/sub> values were significantly lower after ADT than before (<i>p<\/i> &#x3c; 0.05). There were significant correlations between the percent change in CT<sub>LP<\/sub> and the percent change in HbA<sub>1c<\/sub>, between the percent change in LS<sub>ratio<\/sub> and the percent change in abdominal circumference, and between the percent change in LS<sub>dif<\/sub> and the percent change in BMI. <b><i>Conclusions:<\/i><\/b> Six months of ADT was associated with significant progression of NAFLD in PCa patients. This progression was strongly correlated with changes in HbA<sub>1c<\/sub>, abdominal circumference, and BMI. <\/jats:p>","DOI":"10.1159\/000507351","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T21:00:25Z","timestamp":1589317225000},"page":"425-430","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Androgen Deprivation Therapy on Non-Alcoholic Fatty Liver Disease in Patients with Prostate Cancer: A CT Evaluation"],"prefix":"10.1159","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-7664","authenticated-orcid":false,"given":"Harutake","family":"Sawazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1831-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.50"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1042\/cs1040195"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000342814"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2507"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.03.135"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2017.0042"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170587"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091790"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.020"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.5.923"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-69"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13735"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2018.04.004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24051"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170959"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:59:42Z","timestamp":1745423982000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":17,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2020,6,11]]},"published-print":{"date-parts":[[2020,6,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000507351","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}