{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:36:36Z","timestamp":1773858996785,"version":"3.50.1"},"reference-count":49,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. However, there is insufficient knowledge to understand whether there is a causality between the two. Moreover, the impact of vitamin D supplementation on obesity indices has shown inconsistent outcomes. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; This meta-analysis aimed to assess whether vitamin D supplementation modified general and central obesity indices in apparently healthy populations. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A systematic retrieval of relevant randomized controlled trials (RCTs) was undertaken using Pubmed, Embase, Web of Knowledge and Chinese National Knowledge Infrastructure databases. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were used to assess the changes in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and 25-hydroxyvitamin D (25[OH]D) from baseline. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty RCTs involving 3,153 participants reporting either BMI, WC, WHR or 25(OH)D met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant decreases in BMI (WMD = \u20130.09 kg\/m&lt;sup&gt;2&lt;\/sup&gt;, 95% CI \u20130.19 to 0.01, &lt;i&gt;p&lt;\/i&gt; = 0.08), WC (WMD = \u20130.71 cm, 95% CI \u20131.58 to 0.16, &lt;i&gt;p&lt;\/i&gt; = 0.112) or WHR (WMD = 0.00, 95% CI \u20130.01 to 0.01, &lt;i&gt;p&lt;\/i&gt; = 0.749). However, in the subgroups of females, Asia region studies and intervention duration \u22656 months, a beneficial and significant reduction in BMI and WC was noted (all &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.026). On the other hand, pooled results showed that there was a significant increase in serum 25(OH)D levels (WMD = 13.20 ng\/mL, 95% CI 9.83\u201316.58, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) after vitamin D intervention. No publication bias was found in our study. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Overall, supplementation with vitamin D produced no significant effect on the BMI, WC or WHR of healthy adults. <\/jats:p>","DOI":"10.1159\/000507418","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T21:00:33Z","timestamp":1594328433000},"page":"153-164","source":"Crossref","is-referenced-by-count":54,"title":["Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy 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