{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:22:04Z","timestamp":1772706124698,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Impulse control disorder (ICD) in Parkinson\u2019s disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The poor-outcome group showed higher levels of anger expression (&lt;i&gt;p =&lt;\/i&gt;0.007) and obsessive-compulsive traits (&lt;i&gt;p =&lt;\/i&gt;0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD. <\/jats:p>","DOI":"10.1159\/000507447","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T21:00:33Z","timestamp":1590526833000},"page":"171-177","source":"Crossref","is-referenced-by-count":6,"title":["Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson\u2019s Disease"],"prefix":"10.1159","volume":"19","author":[{"given":"Ji-Hyun","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beomseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Beom","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u00a0Tae","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7465-2904","authenticated-orcid":false,"given":"Oh\u00a0Dae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u00a0Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeo-Il","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u00a0Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u00a0Sam\u00a0","family":"Baik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u00a0Whan","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.65"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22356"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.12.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.969"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13078"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.05.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1664"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2000.15.6.609"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201500036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.06.043"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0041-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fc27fa"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.16.3.342"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154433"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.8.1089"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00145"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30004-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8945-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v59n0411"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27689"}],"container-title":["Neurodegenerative 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