{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:18:51Z","timestamp":1794313131405,"version":"4.9.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Anthracycline is used to treat various types of cancer; however, cardiotoxicity negatively affects patient prognosis. <b><i>Objectives:<\/i><\/b> The aim of the present study was to investigate serial changes in levels of cardiac troponin I (TnI) and B-type natriuretic peptide (BNP) in patients treated with anthracycline-containing therapy. <b><i>Methods:<\/i><\/b> 91 consecutive cancer patients planned for anthracycline treatment were enrolled and followed up for 12 months. All patients underwent echocardiography and blood sampling at baseline, 3, 6, and 12 months. <b><i>Results:<\/i><\/b> The patients were divided into two groups based on their TnI level during the follow-up period: the elevated TnI group (TnI \u22650.03 ng\/mL; <i>n<\/i> = 37) and the normal TnI group (<i>n<\/i> = 54). In the elevated TnI group, the TnI levels increased at 3 and 6 months, but they returned to within normal range at 12 months after anthracycline administration. Unlike TnI, the BNP levels began to increase after 6 months, and remained increased at 12 months. The occurrence of cancer therapeutics-related cardiac dysfunction was higher in the elevated TnI group than in the normal TnI group. When we set the cut-off value of TnI at 0.029 ng\/mL, sensitivity and specificity to predict an elevated BNP level of more than 100 pg\/mL were 90 and 63%, respectively. Multivariate logistic regression analysis revealed that elevated TnI was an independent predictor of elevated BNP levels. <b><i>Conclusion:<\/i><\/b> Elevated TnI was an independent predictor for the development of BNP increase. The different characteristics of TnI and BNP should be considered when managing patients treated with anthracycline-containing therapy.<\/jats:p>","DOI":"10.1159\/000507585","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T17:00:33Z","timestamp":1590512433000},"page":"653-660","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac Troponin I Predicts Elevated B-type Natriuretic Peptide in Patients Treated with Anthracycline-Containing Chemotherapy"],"prefix":"10.1159","volume":"98","author":[{"given":"Masayoshi","family":"Oikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiomi","family":"Yoshihisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Yokokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Misaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Yaegashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuchika","family":"Takeishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11407"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu192"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013777"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.095"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.072"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130926.51766.CC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.3404"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.654"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6058"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973321"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1179\/102453312X13376952196412"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14355"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:01:59Z","timestamp":1745409719000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2020,9,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000507585","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}