{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:56:44Z","timestamp":1764277004889,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> The anesthesia procedure in tumor-type total knee arthroplasty (TKA) may contribute to systemic inflammatory response. Therefore, we aim to investigate the effectiveness and safety of general and spinal anesthesia in patients with tumor-type TKA. <b><i>Patients and Methods:<\/i><\/b> Twenty-five patients with tumors around the knee undergoing primary unilateral TKA were randomly divided into the general anesthesia group (<i>n<\/i> = 13) and spinal anesthesia group (<i>n<\/i> = 12). Knee joint HSS scores and Western Ontario and McMaster University osteoarthritis index (WOMAC osteoarthritis) were recorded before surgery and 12 months after surgery. Visual analogue scale, C-reactive protein (CPR), tumor necrosis factor-\u03b1 (TNF-\u03b1), and interleukin-8 (IL-8) concentration were measured preoperatively (T<sub>0<\/sub>), on the day of the operation (T<sub>1<\/sub>), and on the first day (T<sub>2<\/sub>) after the operation. Complications in the two groups were recorded. <b><i>Results:<\/i><\/b> The operative time, intraoperative blood loss, postoperative drainage, tourniquet time, and complication rate were not significantly different between the general anesthesia and spinal anesthesia groups (all <i>p<\/i> &#x3e; 0.05). There were no significant differences in CPR (7.6 \u00b1 3.1, 8.1 \u00b1 4.1, 91.3 \u00b1 24.2 vs. 7.1 \u00b1 2.9, 7.6 \u00b1 3.8, 85.1 \u00b1 19.3 pg\/mL, respectively), IL-8 (12.2 \u00b1 6.6, 13.4 \u00b1 7.3, 19.2 \u00b1 10.5 vs. 11.9 \u00b1 5.7, 12.9 \u00b1 8.6, 22.2 \u00b1 12.4 pg\/mL, respectively), and TNF-\u03b1 (2.5 \u00b1 1.7, 2.2 \u00b1 1.9, 2.8 \u00b1 2.1 vs. 2.4 \u00b1 1.3, 2.7 \u00b1 2.1, 2.9 \u00b1 1.6 pg\/mL, respectively) between the two groups at T<sub>0<\/sub>, T<sub>1<\/sub>, and T<sub>2<\/sub> (all <i>p<\/i> &#x3e; 0.05). There were no statistical differences in pre- and postoperative HSS knee scores (39.78 \u00b1 11.3, 90.24 \u00b1 15.3 vs. 42.68 \u00b1 12.5, 91.21 \u00b1 16.3) and WOMAC indexes (49.89 \u00b1 7.9, 25.12 \u00b1 6.2 vs. 51.3 \u00b1 8.3, 23.15 \u00b1 5.3) between the two groups (<i>p<\/i> &#x3e; 0.05). <b><i>Conclusion:<\/i><\/b> General anesthesia and spinal anesthesia in patients with tumor-type TKA had the same effectiveness and safety. <\/jats:p>","DOI":"10.1159\/000507892","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T21:00:42Z","timestamp":1594933242000},"page":"428-434","source":"Crossref","is-referenced-by-count":5,"title":["The Effectiveness and Safety of General and Spinal Anesthesia on Systemic Inflammatory Response in Patients with Tumor-Type Total Knee Arthroplasty"],"prefix":"10.1159","volume":"43","author":[{"given":"Qiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u00a0Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.3389\/fcell.2017.00103"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1186\/s13018-018-1030-8"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007\/s11914-016-0306-3"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.4055\/cios.2018.10.4.427"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1371\/journal.pone.0158215"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1155\/2014\/205375"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.3928\/01477447-20130327-20"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1002\/jso.23216"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.4161\/viru.27135"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1038\/35013070"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1038\/srep42080"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1159\/000318190"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1007\/s11999-015-4393-8"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1016\/j.jos.2017.05.016"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016\/j.semarthrit.2016.10.012"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1021\/acsbiomaterials.7b00029"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1007\/s11999-013-2980-0"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1007\/s11999-014-4058-z"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1007\/s11999-015-4341-7"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1016\/j.artd.2016.03.005"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016\/j.artd.2017.02.001"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1160\/TH08-07-0421"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1097\/MD.0000000000008433"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1016\/j.knee.2010.03.004"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1097\/AAP.0b013e3181e82e8e"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1007\/s11999-013-3106-4"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.5606\/ehc.2016.31"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1186\/s12871-017-0354-y"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/507892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:04:42Z","timestamp":1745424282000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000507892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,4]]},"published-print":{"date-parts":[[2020,9,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000507892","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2020]]}}}