{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:51:07Z","timestamp":1792047067788,"version":"4.4.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Fetal growth restriction (FGR) is associated with neonatal and long-term neuro-morbidity. Preferential redistribution of blood flow to the brain is a common antenatal adaptation in FGR. The impact of this \u201cbrain sparing,\u201d which may signify severity of FGR, on the growth of brain structures has not been studied. <b><i>Aim:<\/i><\/b> To compare corpus callosum (CC), cerebellar, and ventricular measurements of FGR neonates with evidence of fetal blood flow redistribution with those of gestation-matched appropriately grown (AGA) neonates. <b><i>Methods:<\/i><\/b> This was a pilot, prospective observational study conducted at a tertiary level neonatal unit in Melbourne, Australia. Cranial ultrasound was done between days 1 and 3 of life in FGR and AGA neonates. <b><i>Results:<\/i><\/b> Cranial ultrasound on 20 FGR, gestation (mean \u00b1 SD) 31.4 \u00b1 3.1 weeks, weight 1,205 \u00b1 463 g, and 20 AGA neonates, 31.1 \u00b1 3.0 weeks, 1,668 \u00b1 490 g, was performed. CC length was significantly decreased in FGR neonates as compared to AGA neonates (35.28 \u00b1 3.47 vs. 38.83 \u00b1 4.05 mm, <i>p<\/i> = 0.0002). CC was significantly thinner at genu (3.36 \u00b1 0.66 vs. 4.04 \u00b1 0.83 mm, <i>p<\/i> = 0.007), body (1.97 \u00b1 0.36 vs. 2.27 \u00b1 0.39 mm, <i>p<\/i> = 0.02), and splenium (4.07 \u00b1 0.76 vs. 4.72 \u00b1 0.75 mm, <i>p<\/i> = 0.003) in FGR vs. AGA neonates. CC-fastigium length was also significantly decreased (39.65 \u00b1 3.87 vs. 41.96 \u00b1 4.50 mm, <i>p<\/i> = 0.04). Similarly, FGR neonates showed decreased transverse cerebellar diameter (36.15 \u00b1 5.51 vs. 38.81 \u00b1 7.21 mm, <i>p<\/i> = 0.02), but ventricular measurements were comparable. In multivariate analysis, these differences were evident independent of the birth weight. <b><i>Conclusions:<\/i><\/b>CC and cerebellar measurements are significantly smaller in FGR neonates with fetal blood flow redistribution, which warrants further study. <\/jats:p>","DOI":"10.1159\/000508001","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T21:00:33Z","timestamp":1591909233000},"page":"446-452","source":"Crossref","is-referenced-by-count":9,"title":["Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study"],"prefix":"10.1159","volume":"117","author":[{"given":"Pramod","family":"Pharande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Whiteley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Sasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-4182","authenticated-orcid":false,"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00055"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9041"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.028"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.02.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(90)90029-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000128983.54614.7E"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.746300"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00775.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5278"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4088"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11331"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.10.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110334"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4381"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4731"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh230"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6661(200005\/06)9:3<155::AID-MFM1>3.0.CO;2-L"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1022863"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6343"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.12.008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13808"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.032"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2343"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1113\/JP271402"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:05:50Z","timestamp":1745424350000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,2]]},"published-print":{"date-parts":[[2020,12,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000508001","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}