{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:54:23Z","timestamp":1769126063744,"version":"3.49.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The factors associated with a low plasma xanthine oxidoreductase (XOR) activity were not elucidated in patients with acute heart failure (AHF). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Two-hundred and twenty-nine AHF patients who visited the emergency department were prospectively analyzed. AHF patients were divided into 3 groups according to the plasma XOR quartiles (Q1 = low-XOR group [&lt;i&gt;n&lt;\/i&gt; = 57], Q2\/Q3 = middle-XOR group [&lt;i&gt;n&lt;\/i&gt; = 115], and Q4 = high-XOR group [&lt;i&gt;n&lt;\/i&gt; = 57]). The prognostic nutritional index (PNI) and the controlling nutritional status (CONUT) score were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The multivariate logistic regression model showed that the nutritional status (PNI: OR 1.044, 95% CI 1.000\u20131.088; CONUT: OR 3.805, 95% CI 1.158\u201312.498), age, and serum creatinine level were independently associated with a low plasma XOR activity. The Kaplan-Meier curve showed a significantly lower incidence of heart failure events in the low-XOR group than in the middle + high-XOR group (hazard ratio, HR 1.648, 95% CI 1.061\u20132.559). In particular, a low XOR activity with an increased serum creatinine level (&amp;#x3e;1.21 mg\/dL) was independently associated with heart failure events (HR 1.937, 95% CI 1.199\u20133.130). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A low plasma XOR activity was associated with malnutrition, renal dysfunction, and aging in AHF. A low XOR activity complicated with renal dysfunction leads to adverse long-term outcomes. <\/jats:p>","DOI":"10.1159\/000508037","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T21:00:32Z","timestamp":1593723632000},"page":"473-480","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of Patients with an Abnormally Decreased Plasma Xanthine Oxidoreductase Activity in Acute Heart Failure Who Visited the Emergency Department"],"prefix":"10.1159","volume":"145","author":[{"given":"Akihiro","family":"Shirakabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotake","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Goda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Shigihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennichi","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayo","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-4779","authenticated-orcid":false,"given":"Nobuaki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritake","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniya","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2010.527823"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-013-9698-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.077"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12390"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9714710"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1414"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.05.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.11.030"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3390"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.10.033"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182699"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-018-1207-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000056762.69302.46"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0413-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119888"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0908-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230405"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1997.0858"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9540-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-014-0189-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.08.022"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-017-1034-z"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1523-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2019.03.005"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:06:18Z","timestamp":1745424378000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,5]]},"published-print":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000508037","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}