{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:52:00Z","timestamp":1792929120287,"version":"4.5.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Cyst compression of renal tubules plays a role in the progression of autosomal dominant polycystic kidney disease (ADPKD) and may induce expression of kidney injury molecule-1 (KIM-1). Whether urinary KIM-1 indexed for creatinine (uKIM-1\/Cr) is a prognostic marker of disease progression in ADPKD is unknown.<b><i><\/i><\/b>In this secondary analysis of a prospective cohort study, we sought to determine whether patients with high as opposed to low uKIM-1\/CR at baseline had greater rates of eGFR loss and height-adjusted total kidney volume (HtTKV) increase. <b><i>Methods:<\/i><\/b> Baseline uKIM-1\/Cr values were obtained from 754 participants in Halt Progression of Polycystic Kidney Disease (HALT-PKD) studies A (early ADPKD) and B (late ADPKD). The predictor was uKIM-1\/Cr, which was dichotomized by a median value of 0.2417 pg\/g, and the primary outcomes were measured longitudinally over time. Mixed-effects linear models were used in the analysis to calculate the annual slope of change in eGFR and HtTKV. <b><i>Results:<\/i><\/b> Patients with high uKIM-1\/Cr (above the median) had an annual decline in eGFR that was 0.47 mL\/min greater than that in those with low uKIM-1\/Cr (<i>p<\/i> = 0.0015) after adjustment for all considered covariates. This association was seen in study B patients alone (0.45 mL\/min; <i>p<\/i> = 0.009), but not in study A patients alone (0.42 mL\/min; <i>p<\/i> = 0.06). High baseline uKIM-1\/Cr was associated with higher HtTKV in the baseline cross-sectional analysis compared to low uKIM-1\/Cr (<i>p<\/i> = 0.02), but there was no difference between the groups in the mixed-effects model annual slopes. <b><i>Conclusion:<\/i><\/b> Elevated baseline uKIM-1\/Cr is associated with a greater decline in eGFR over time. Further research is needed to determine whether uKIM-1\/Cr improves risk stratification in patients with ADPKD.<\/jats:p>","DOI":"10.1159\/000508051","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T17:01:20Z","timestamp":1592240480000},"page":"473-479","source":"Crossref","is-referenced-by-count":16,"title":["KIM-1 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease: HALT-PKD Results"],"prefix":"10.1159","volume":"51","author":[{"given":"Benjamin\u00a0R.","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Noureddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-6497","authenticated-orcid":false,"given":"Berenice","family":"Gitomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loni","family":"Perrenoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chonchol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Jalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the\u00a0HALT\u00a0Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.59"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054341"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.01.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33379"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101138"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6061778"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.7.4135"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/path.2175"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.05.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.109"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111184"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402685"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402686"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04310709"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040325"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0114-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-2041-4_3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00291.2005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000589"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0973"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070530"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.06.023"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123555"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:06:30Z","timestamp":1745409990000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,24]]},"published-print":{"date-parts":[[2020,7,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000508051","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}