{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:00:12Z","timestamp":1754600412482,"version":"3.40.5"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Purpose:<\/i><\/b> The aim of this study was to compare the management outcome of endophthalmitis with and without the use of topical antibiotics. <b><i>Methods:<\/i><\/b> A retrospective comparative chart review of 2 cohorts of endophthalmitis (other than those associated with open-globe injury, keratitis, or wound site infection), one managed with topical antibiotics (TA group) and one without (NTA group), was performed. <b><i>Results:<\/i><\/b> The study included a total of 270 eyes of 270 patients. Of these, 169 eyes were in the TA group and 101 were in the NTA group. Post-cataract surgery was the most common etiology, accounting for 81.06 and 78.2% of cases, respectively (<i>p<\/i> = 0.57). A favorable functional outcome at the last visit was seen in 37.5 and 39.6% of eyes (<i>p<\/i> = 0.73), and a favorable anatomic outcome was noted in 61.2 and 49.5% of eyes (<i>p<\/i> = 0.06), respectively. The median follow-up was 3.5 and 9 months, respectively (<i>p<\/i> &#x3c; 0.0001). Susceptibilities to the common antibiotics used (vancomycin, ceftazidime, and amikacin) were comparable, with the exception of imipenem, for which the susceptibility noted was 95 and 66%, respectively (<i>p<\/i> = 0.01). Culture positivity in the TA group was seen in 72 out of 169 eyes (42.6%), while in the NTA group it was seen in 98 out of 101 eyes (97.02%; <i>p<\/i> &#x3c; 0.0001). <b><i>Conclusion:<\/i><\/b> Topical antibiotics do not give any added advantage in the management of endophthalmitis otherwise being treated with intravitreal antibiotics and standard vitrectomy techniques. <\/jats:p>","DOI":"10.1159\/000508133","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T21:00:33Z","timestamp":1587762033000},"page":"208-212","source":"Crossref","is-referenced-by-count":2,"title":["Management of Endophthalmitis with and without Topical Antibiotics: A Case-Control Study"],"prefix":"10.1159","volume":"244","author":[{"given":"Vivek\u00a0Pravin","family":"Dave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Pathengay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumar","family":"Nishant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-7334","authenticated-orcid":false,"given":"Venkata\u00a0Shubakar","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev\u00a0Reddy","family":"Pappuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taraprasad","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100120009001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-014-0022-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(82)90080-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/157488410790410597"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200509000-00011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.1.39"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702414"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200602000-00012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.213"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3608-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.83903"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:19Z","timestamp":1745424439000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,24]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,1]]},"published-print":{"date-parts":[[2021,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000508133","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"type":"print","value":"0030-3755"},{"type":"electronic","value":"1423-0267"}],"subject":[],"published":{"date-parts":[[2020,4,24]]}}}