{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:24:16Z","timestamp":1791822256882,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> <i>Helicobacter pylori<\/i>is responsible for a wide spectrum of diseases. Due to ease of use and access, the standard triple therapy is being used as first-line eradication in many areas. Intestinal metaplasia (IM) is a precancerous lesion that requires eradication therapy. Our aim is to investigate the effect of IM on the standard triple therapy success in <i>H. pylori<\/i>-positive patients. <b><i>Subjects and Methods:<\/i><\/b> The patients who were referred to D\u00fczce University Hospital and Avrasya Hospital Gastroenterohepatology clinic between January 2014 and December 2016 and diagnosed with <i>H. pylori<\/i>-positive gastritis and underwent first-line eradication were evaluated retrospectively. Biopsy specimens were evaluated according to the updated Sydney system. All patients diagnosed with <i>H. pylori<\/i> started treatment with pantoprazole 40 mg b.i.d., amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 14 days. <b><i>Results:<\/i><\/b> The mean age of 181 patients included in the study was 55.5 \u00b1 7.8. The success rate of <i>H. pylori<\/i> eradication was found to be low in severe chronic inflammation (<i>p<\/i> = 0.001). The success rate was found to be high among patients with no neutrophil activity (<i>p<\/i> = 0.009). As the intensity of IM increased, density of <i>H. pylori<\/i> was found to be decreased (<i>p<\/i> = 0.019). There was no correlation between glandular atrophy, IM, and <i>H. pylori<\/i> eradication success rate (<i>p<\/i> = 0.390 and <i>p<\/i> = 0.812). <b><i>Conclusion:<\/i><\/b> The severity of chronic inflammation is the most effective Sydney criteria for success of eradication, while the presence on IM does not have any effect. <\/jats:p>","DOI":"10.1159\/000508248","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T21:00:28Z","timestamp":1588107628000},"page":"551-557","source":"Crossref","is-referenced-by-count":4,"title":["The Relationship between the Sydney Classification and the First-Line Treatment Efficacy in <b><i>Helicobacter<\/i><\/b>-Associated Gastritis"],"prefix":"10.1159","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-1628","authenticated-orcid":false,"given":"Elif","family":"\u015eenocak\u00a0Ta\u015f\u00e7\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcrkay","family":"Akba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00248.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v5.i2.101"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb01468.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.5.1669-1673.1995"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199700001-00035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91820-T"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0896-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.99299.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0563-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.25.11.2123-2125.1987"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12609"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/434039"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.9.679"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90455-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90340-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898634"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1999.40.4.392"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7869\/tg.261"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2013.05.005"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:38Z","timestamp":1745424518000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,9]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000508248","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}