{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:30:49Z","timestamp":1790353849564,"version":"4.1.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Bone involvement in Hodgkin lymphoma (HL) is rare. The differential diagnosis between HL bone localization and other malignant or benign skeletal diseases is challenging. We report the case of a girl affected by classic HL, initially staged IVA because of supradiaphragmatic lymph nodes and skeletal involvement. After 6 ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) cycles, positron emission tomography (PET) showed a complete metabolic response of the nodal localizations and a persistent, high metabolic activity of bone lesions. Salvage treatment followed by autologous stem cell transplant was carried out. After the transplant, the bone lesions maintained a high metabolic activity at PET. A targeted bone biopsy led to the diagnosis of a fibrous dysplasia excluding the presence of HL. To our knowledge, the concomitant presence of HL and fibrous dysplasia has not been previously reported. An in-depth evaluation of disease response to frontline treatment with a biopsy of the PET-hypercaptant bone lesions could have avoided overtreatment in this patient. <\/jats:p>","DOI":"10.1159\/000508261","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T21:00:37Z","timestamp":1595624437000},"page":"212-217","source":"Crossref","is-referenced-by-count":1,"title":["Polyostotic Fibrous Dysplasia Mimicking Bone Involvement in Hodgkin Lymphoma: A Pediatric Case and Literature Review"],"prefix":"10.1159","volume":"144","author":[{"given":"Gianfranco","family":"Lapietra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Luisa","family":"Moleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorina","family":"Giona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Turchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Celli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Corsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"D'Avanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Celli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u00a0Maria","family":"Testi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-6-34"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000490489"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.205633"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.1.g01ja02161"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2147\/PLMI.S24866"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000242"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000170058.73956.82"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2009.41.3.171"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31817793bb"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-012-0171-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000600"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2131859"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF01367602"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1166::AID-CNCR22>3.0.CO;2-V"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-S1-S2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.167.6.8956590"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199901)187:2<249::AID-PATH222>3.0.CO;2-J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28142"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:46Z","timestamp":1745424526000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,3,24]]},"published-print":{"date-parts":[[2021,3,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000508261","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12705770","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]}}}