{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:10:30Z","timestamp":1780445430662,"version":"3.54.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Epileptic seizures are common in the elderly Down syndrome population. We encountered a patient with Down syndrome in whom karyotyping showed the rare isodicentric chromosome 21 and who suffered from myoclonic seizures. A 52-year-old woman with Down syndrome experienced sudden onset of drowsiness and frequent myoclonic jerks in the upper body. Video-EEG recordings demonstrated generalized polyspike-wave discharges consistent with myoclonic jerks, which were exacerbated by photo-stimulation. Her myoclonus completely resolved with perampanel administration. Perampanel was effective for myoclonic seizures in our patient. We suggest that perampanel is an option as first-line therapy for epilepsy and myoclonus in elderly Down syndrome patients. <\/jats:p>","DOI":"10.1159\/000508357","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T21:04:20Z","timestamp":1599771860000},"page":"270-275","source":"Crossref","is-referenced-by-count":4,"title":["The Effectiveness of Perampanel for Myoclonic Seizures in Down Syndrome with Isodicentric Chromosome 21"],"prefix":"10.1159","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-5607","authenticated-orcid":false,"given":"Koji","family":"Obara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Imota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Mamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Toyoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2210"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.04.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7376-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38497"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.08.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02680.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14456"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.07.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2019.100215"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S154388"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.02.022"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:09:59Z","timestamp":1745424599000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000508357","archive":["Portico"],"relation":{},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]}}}