{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:37:47Z","timestamp":1764401867031,"version":"3.40.5"},"reference-count":60,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients. <\/jats:p>","DOI":"10.1159\/000508395","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T21:00:33Z","timestamp":1591909233000},"page":"520-531","source":"Crossref","is-referenced-by-count":2,"title":["Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm"],"prefix":"10.1159","volume":"64","author":[{"given":"Andrea","family":"Ronchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-3869","authenticated-orcid":false,"given":"Alessandro","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-5925","authenticated-orcid":false,"given":"Pio","family":"Zeppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Colella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immacolata","family":"Cozzolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20429"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22162"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.02.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.07.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20637"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0381"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.11.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.06.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.04.034"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182997d52"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.05.024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21629"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00618.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.03.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0266-4356(02)00117-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10168"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.12.1435"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s1368-8375(00)00033-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.3.8109517"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810601)47:11%26lt;2712::aid-cncr2820471130%26gt;3.0.co;2-a"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25681"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24177"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0339(20000301)22:3%26lt;139::aid-dc2%26gt;3.0.co;2-a"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24120"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0339(199708)17:2%26lt;92::aid-dc3%26gt;3.0.co;2-q"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.02.020"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/00016486409121406"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-09-0638"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90262-3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196807)22:1%3c;111::aid-cncr2820220114%3e;3.0.co;2-j"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000566"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00122-F"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.03.003"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197604000-00016"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.05.031"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3109\/08880019509029592"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20188"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199911000-00017"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20306"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100109752"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(92)90083-2"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-015-0757-0"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891115)64:10%26lt;2174::aid-cncr2820641032%26gt;3.0.co;2-f"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/s0748-7983(95)96251-4"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1080\/08880010151114903"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1981.01380150053014"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401948"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109991526"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(95)90080-2"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20832"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182468c55"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21002"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.673696"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.136032"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1080\/003655402_000028048"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.004"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.4103\/ams.ams_179_18"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2003.10.002"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-546"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.03.009"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:16Z","timestamp":1745424616000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,2]]},"published-print":{"date-parts":[[2020,11,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000508395","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2020]]}}}