{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:30:20Z","timestamp":1782603020967,"version":"3.54.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> This study aimed to demonstrate the clinical features and postoperative outcomes of extrahepatic bile duct (EHBD) neuroendocrine carcinoma (NEC) and compared with those of adenocarcinoma. <b><i>Methods:<\/i><\/b> We retrospectively analyzed patients with EHBD cancer operated in our institution between 1995 and 2015. <b><i>Results:<\/i><\/b> Of 475 patients, 468 had adenocarcinoma, while 7 had NEC\/mixed adenoneuroendocrine carcinoma (MANEC) in this study. There were no notable preoperative and pathological features in patients with NEC\/MANEC. However, patients with NEC\/MANEC had a higher recurrence rate (51.8 vs. 100%, <i>p<\/i> = 0.016), poorer relapse-free survival (RFS) time (the median RFS time: 35 vs. 12 months, <i>p<\/i> = 0.006), and poorer overall survival (OS) time (the median OS time: 60 vs. 19 months, <i>p<\/i> = 0.078) than those with adenocarcinoma. Furthermore, patients with NEC\/MANEC had higher rates of liver metastasis (11.9 vs. 85.7%, <i>p<\/i> &#x3c; 0.001) than those with adenocarcinoma. In multivariable regression analysis, pathological type with NEC\/MANEC was a risk factor for poorer RFS (<i>p<\/i> = 0.022, hazard ratio: 6.09). <b><i>Conclusions:<\/i><\/b> Patients with NEC\/MANEC have high malignant potential and poor outcomes. It is necessary to develop an effective approach and postoperative adjuvant treatment for patients with NEC\/MANEC. <\/jats:p>","DOI":"10.1159\/000508443","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T21:00:34Z","timestamp":1592859634000},"page":"30-37","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma"],"prefix":"10.1159","volume":"38","author":[{"given":"Masahiro","family":"Shiihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2009.08.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0110001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1261938"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0191-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i28.4616"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-0951-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds276"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.07.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-003-2594-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0843-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-009-0051-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9808-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3181b0fc8b"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.283"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5381"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S157156"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp173"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000338794"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12473"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:41Z","timestamp":1745424641000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000508443","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12526631","asserted-by":"subject"}]},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}