{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:51:19Z","timestamp":1792176679002,"version":"4.4.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Glossopharyngeal neuralgia (GPN) is a rare facial pain syndrome with debilitating symptoms. For medication-resistant GPN, stereotactic radiosurgery (SRS) is an emerging treatment option with a promising role; however, recurrence rates after SRS are fairly high. We present a patient who underwent repeat SRS for recurrent GPN and subsequently maintained over 3 years of complete pain relief. For the first time, we present a systematic review of repeat SRS for recurrent GPN. <b><i>Summary:<\/i><\/b> Twelve cases of repeat SRS for GPN have previously been reported in the literature (13 studies including ours). Among patients with follow-up, initial pain relief was achieved in 83% (<i>n<\/i> = 10) of cases a median of 5 weeks after repeat SRS; 2 patients failed to obtain any pain relief. A favorable pain response (BNI I\u2013IIIb) was achieved in 67 and 58% of cases at 6 and 12 months, respectively. All 13 were targeted to the glossopharyngeal meatus. Three patients (23%) experienced adverse radiation effects. Five patients (50%) experienced recurrence a median of 14 months after repeat SRS. Two patients (17%) required additional surgical intervention. At the final follow-up, 75% (<i>n<\/i> = 9) of the patients had a favorable pain outcome. <b><i>Key Messages:<\/i><\/b> Repeat SRS may be a viable alternative to open surgery for the treatment of recurrent GPN, albeit with an increased risk of adverse radiation effects. Though limited by a small cohort of patients, the best predictors of an effective second treatment may be a response to initial SRS for &#x3e;5 months, a maximum dose &#x3e;75 Gy, and a target at the glossopharyngeal meatus. Larger prospective studies are needed to better define its role. <\/jats:p>","DOI":"10.1159\/000508541","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T21:01:45Z","timestamp":1597784505000},"page":"324-330","source":"Crossref","is-referenced-by-count":9,"title":["Repeat Gamma Knife Radiosurgery for Recurrent Glossopharyngeal Neuralgia: A Systematic Review and Our Initial Experience"],"prefix":"10.1159","volume":"98","author":[{"given":"Joel","family":"Kaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekhaj\u00a0C.","family":"Daggubati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McInerney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2909-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000110283"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2302-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417698961"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.JNS162542"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171\/2016.7.GKS161523"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171\/2011.5.JNS1133"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3171\/2008.8.17641"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-017-0886-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-019-04124-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00513-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-03789-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09694"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS142144"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171\/2017.9.JNS17545"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.09.042"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-017-3347-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3171\/2012.12.FOCUS12391"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2019.01.013"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.GKS141487"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:41Z","timestamp":1745424701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,22]]},"published-print":{"date-parts":[[2020,9,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000508541","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}