{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:37:08Z","timestamp":1774460228775,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Fentanyl is a commonly used off-label medication for pain control and sedation in preterm infants. Yet, the effect of fentanyl on cerebral hemodynamics in preterm neonates remains unexplored. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate the effect of a bolus dose of fentanyl on the regional cerebral oxygen saturation (RcSO&lt;sub&gt;2&lt;\/sub&gt;), cerebral fractional tissue oxygen extraction (cFTOE) and left ventricular output (LVO) as compared with pre-administration baseline in preterm infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a prospective observational study conducted in a level III Canadian NICU from September 2017 to February 2019. Preterm infants born &amp;#x3c;37 weeks of gestation and scheduled to receive a fentanyl bolus (1\u20132 \u03bcg\/kg\/dose) were eligible. Infants with major congenital anomalies, medically unstable and those who had received fentanyl in the previous 48 h were excluded. &lt;b&gt;&lt;i&gt;Outcomes:&lt;\/i&gt;&lt;\/b&gt; The primary outcome was the difference between RcSO&lt;sub&gt;2&lt;\/sub&gt; measured 5 min prior to and RcSO&lt;sub&gt;2&lt;\/sub&gt; measured at defined time points after administration of fentanyl. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty-eight infants were enrolled during the study period (median gestational age 28 weeks; interquartile range [IQR] 25\u201329 weeks; median birth weight 1,035 g [IQR 830\u20131,292 g]; median age 4 days [IQR 3\u20137 days]). Mean (\u00b1standard deviation) baseline RcSO&lt;sub&gt;2&lt;\/sub&gt; was 73.6% (\u00b111.8), cFTOE was 21.9 (\u00b111.2) and LVO was 380 (\u00b1147) mL\/kg\/min prior to fentanyl infusion. One-way ANOVA showed no statistically significant difference between baseline and any of the post-fentanyl cerebral oxygenation, tissue oxygen extraction or cardiac output measures (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Administration of fentanyl bolus for procedural pain and sedation was not shown to significantly affect cerebral oxygenation, cerebral tissue oxygen extraction or cardiac output in stable preterm infants. <\/jats:p>","DOI":"10.1159\/000508555","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T21:00:34Z","timestamp":1594242034000},"page":"480-487","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational 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