{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:30Z","timestamp":1790162910619,"version":"4.1.0"},"reference-count":39,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; There are limited data on outcomes of patients undergoing peripheral arterial disease (PAD) interventions who have comorbid CKD\/ESRD versus those who do not have such comorbid condition. We performed a systematic review and meta-analysis to analyze outcomes in this patient population. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Five databases were searched for studies comparing outcomes of lower extremity PAD interventions for claudication and critical limb ischemia (CLI) in patients with CKD\/ESRD versus non-CKD\/non-ESRD from January 2000 to June 2019. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Our study included 16 observational studies with 44,138 patients. Mean follow-up was 48.9 \u00b1 27.4 months. Major amputation was higher with CKD\/ESRD compared with non-CKD\/non-ESRD (odds ratio [OR 1.97] [95% confidence interval [CI] 1.39\u20132.80], &lt;i&gt;p&lt;\/i&gt; = 0.001). Higher major amputations with CKD\/ESRD versus non-CKD\/non-ESRD were only observed when indication for procedure was CLI (OR 2.27 [95% CI 1.53\u20133.36], &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001) but were similar for claudication (OR 1.15 [95% CI 0.53\u20132.49], &lt;i&gt;p&lt;\/i&gt; = 0.72). The risk of early mortality was high with CKD\/ESRD patients undergoing PAD interventions compared with non-CKD\/non-ESRD (OR 2.55 [95% CI 1.65\u20133.96], &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001), which when stratified based on indication, remained higher with CLI (OR 3.14 [95% CI 1.80\u20135.48], &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001) but was similar with claudication (OR 1.83 [95% CI 0.90\u20133.72], &lt;i&gt;p&lt;\/i&gt; = 0.1). Funnel plot of included studies showed moderate bias. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Patients undergoing lower extremity PAD interventions for CLI who also have comorbid CKD\/ESRD have an increased risk of experiencing major amputations and early mortality. Randomized trials to understand outcomes of PAD interventions in this at-risk population are essential. <\/jats:p>","DOI":"10.1159\/000508575","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T21:00:34Z","timestamp":1592859634000},"page":"527-533","source":"Crossref","is-referenced-by-count":13,"title":["Impact of Kidney Disease on Peripheral Arterial Interventions: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-7406","authenticated-orcid":false,"given":"Mahesh","family":"Anantha-Narayanan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar Bilal","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Nagpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim 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