{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:12Z","timestamp":1790630412905,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Alstr\u00f6m syndrome is a rare recessive genetic disease caused by mutations in <i>ALMS1<\/i>, which encodes a protein that is related to cilia function and intracellular endosome trafficking. The syndrome has been linked to impaired glucose metabolism and CKD. Polymorphisms in <i>Alms1<\/i> have likewise been linked to CKD, but little is known about the modification of the phenotype by environmental factors. <b><i>Methods:<\/i><\/b> To gain further insights, the fat aussie (<i>foz<\/i>) mouse strain, a genetic murine model of Alstr\u00f6m syndrome, was exposed to a normal chow (NC) or to a Western diet (WD, 20% fat, 34% sucrose by weight, and 0.2% cholesterol) and renal outcomes were measured. <b><i>Results:<\/i><\/b> Body weight and albuminuria were higher in <i>foz<\/i> than in wild-type (WT) mice on both diets but WD significantly increased the difference. Measurement of plasma creatinine and cystatin C indicated that glomerular filtration rate was preserved in <i>foz<\/i> versus WT independent of diet. Renal markers of injury, inflammation, and fibrosis were similar in both genotypes on NC but significantly greater in <i>foz<\/i> than in WT mice on WD. A glucose tolerance test performed in <i>foz<\/i> and WT mice on WD revealed similar basal blood glucose levels and subsequent blood glucose profiles. <b><i>Conclusions:<\/i><\/b> WD sensitizes a murine model of Alstr\u00f6m syndrome to kidney injury, inflammation, and fibrosis, an effect that may not be solely due to effects on glucose metabolism. Polymorphisms in <i>Alms1<\/i> may induce CKD in part by modulating the deleterious effects of high dietary fat and sucrose on kidney outcome. <\/jats:p>","DOI":"10.1159\/000508636","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T21:00:34Z","timestamp":1594069234000},"page":"400-412","source":"Crossref","is-referenced-by-count":10,"title":["Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstr\u00f6m Syndrome"],"prefix":"10.1159","volume":"144","author":[{"given":"Young Chul","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souradipta","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josselin","family":"Nespoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debanjan","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Vallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1581"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ng867"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ng874"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22796"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.6.675"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.568"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.07.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0494"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi235"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95076"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037925"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12335"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v81.6.1607.bloodjournal8161607"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.116"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.2.812"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.032"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05996.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.462"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00013.2012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.009340"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.019"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm743"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101105"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00427.2012"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002292"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:13:08Z","timestamp":1745424788000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,5]]},"published-print":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000508636","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}