{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:33:26Z","timestamp":1789706006666,"version":"4.0.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Angiotensin-converting enzyme inhibitors (ACEI) combined with mineralocorticoid receptor antagonists were found to have a beneficial effect on patients with chronic kidney disease. <b><i>Objective:<\/i><\/b> The aim of our clinical trial was to compare the antialbuminuric effect of ramipril monotherapy, eplerenone monotherapy and eplerenone\/ramipril combination therapy in patients with stage 1 hypertension and type 2 diabetes mellitus. <b><i>Methods:<\/i><\/b> In a single-blind, randomized clinical trial, 75 hypertensive patients (stage 1 hypertension) with type 2 diabetes mellitus and microalbuminuria were randomized in a 1:1:1 ratio to 1 of 3 groups: ramipril 10 mg monotherapy (25 patients), eplerenone 50 mg monotherapy (25 patients) and combination therapy of eplerenone\/ramipril 50\/10 mg (25 patients) through a randomized clinical trial. Blood pressure, urinary albumin\/creatinine ratio (UACR), serum creatinine, estimated glomerular filtration rate (eGFR) and serum K level were measured before randomization and after 24 weeks. <b><i>Results:<\/i><\/b> Ramipril and eplerenone monotherapy showed a significant lowering of UACR compared with baseline levels (<i>p<\/i> \u2264 0.0001). The eplerenone\/ramipril combination group showed a more significant reduction of UACR compared with the ramipril and eplerenone monotherapy groups (<i>p<\/i> = 0.0001). There was a more significant lowering of systolic blood pressure in the combination group (<i>p<\/i> &#x3c; 0.0001). A nonsignificant change of serum potassium level, serum creatinine and eGFR was found among the 3 groups. <b><i>Conclusion:<\/i><\/b> Addition of eplerenone to ACEI shows an added antialbuminuric effect without significant change of the serum K level compared with eplerenone or ACEI. <\/jats:p>","DOI":"10.1159\/000508670","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:00:33Z","timestamp":1601499633000},"page":"392-401","source":"Crossref","is-referenced-by-count":27,"title":["A Prospective Single-Blind Randomized Trial of Ramipril, Eplerenone and Their Combination in Type 2 Diabetic Nephropathy"],"prefix":"10.1159","volume":"10","author":[{"given":"Mostafa","family":"El\u00a0Mokadem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Abd\u00a0El\u00a0Hady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121273"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-1-10"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00131.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000382028"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.62090"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834d9e0f"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006540"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2007.S79"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.10.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121288"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.713"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00213.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12629"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1106-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft281"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240106"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000044937.95080.E9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1542-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.11.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00805-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000025146.19104.FE"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.5.685"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1470320311412811"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.04889"}],"container-title":["Cardiorenal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:13:36Z","timestamp":1745424816000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,4]]},"published-print":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000508670","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13026146","asserted-by":"subject"}]},"ISSN":["1664-3828","1664-5502"],"issn-type":[{"value":"1664-3828","type":"print"},{"value":"1664-5502","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}