{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:51:35Z","timestamp":1793173895484,"version":"4.5.0"},"reference-count":43,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Age-related macular degeneration (AMD) causes irreversible vision loss, and targeted anti-vascular endothelial growth factor (VEGF) therapy is now the most common and effective treatment. The aim of this meta-analysis is to discuss whether genetic polymorphism of &lt;i&gt;ARMS2&lt;\/i&gt; A69S could confer susceptibility to advanced AMD with the response to anti-VEGF treatment. We performed a meta-analysis of relevant published studies selected through electronic databases. A total of 21 preferred studies regarding the association between &lt;i&gt;ARMS2&lt;\/i&gt; gene and anti-VEGF treatment response in advanced AMD were generally included in the meta-analysis. The pooled results demonstrated that the carriage of G allele for &lt;i&gt;ARMS2&lt;\/i&gt; A69S presented a better clinical prognosis for advanced AMD treated with anti-VEGF drugs (OR = 1.38, 95% CI = 1.13\u20131.69, &lt;i&gt;p&lt;\/i&gt; = 0.002). In addition, in the subgroup analysis based on ethnicity, &lt;i&gt;ARMS2&lt;\/i&gt; polymorphisms were more likely to be a positive responder for East Asian patients (OR = 1.67, 95% CI = 1.29\u20132.16, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). This meta-analysis through a series of rigorous methodology data demonstrated a significant association between &lt;i&gt;ARMS2&lt;\/i&gt; A69S polymorphism and the anti-VEGF treatment response in advanced AMD, especially among East Asian population. Numerous well-designed, randomized, multicenter clinical trials with large sample size are required to validate the association. <\/jats:p>","DOI":"10.1159\/000508738","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T21:00:34Z","timestamp":1589922034000},"page":"192-204","source":"Crossref","is-referenced-by-count":13,"title":["Meta-Analysis of the Pharmacogenetics of &lt;b&gt;&lt;i&gt;ARMS2&lt;\/i&gt;&lt;\/b&gt; A69S Polymorphism and the Response to Advanced Age-Related Macular Degeneration"],"prefix":"10.1159","volume":"64","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00495-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.564"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.10.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.04.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60282-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61501-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.825292"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2014.11.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.07.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703933104"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3850"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.11.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31822a2c7c"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318225290f"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.01.010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/676049"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.11.037"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S39635"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.046"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.14.51"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182979e1e"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2014.949010"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2688-1"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.053"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15049164"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000446819"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/srep44020"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0631-z"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09632-0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-019-0197-3"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc063011"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102673"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.015"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/ng.170"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133807"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0487-2"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305488"}],"container-title":["Ophthalmic 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