{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T18:46:04Z","timestamp":1776192364368,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> There are gaps in the literature regarding outcome of multiple polyps and dilemmas in the management issues in polyposis syndromes in children. <b><i>Objective:<\/i><\/b> We aimed to study the clinical behaviour of gastrointestinal (GI) polyps with emphasis on therapeutic outcomes of polyposis syndrome. <b><i>Methods:<\/i><\/b> Proven cases of GI polyp(s) on endoscopy were classified as single polyp, multiple polyps, and polyposis syndrome. Complex presentation was defined as 1 or more of the following: severe anaemia, anasarca, intussusception, rectal mucosal prolapse, and diarrhoea. A clinico-endoscopic criterion was applied in polyposis syndrome patients for the decision of surgery versus endoscopic therapy with surveillance. <b><i>Results:<\/i><\/b> Of total 240 patients, there were no significant differences between single (52.5%, <i>n<\/i> = 126) versus multiple polyps (27.5%, <i>n<\/i> = 66) with respect to age, symptoms, histology, and recurrence. Polyposis syndrome (20%, <i>n<\/i> = 48) presented with complex symptoms (50%), higher family history, significantly lower haemoglobin, total protein, and albumin as compared to single and multiple polyps (<i>p<\/i> &#x3c; 0.01). Nineteen polyposis patients with favourable clinico-endoscopic criteria were endoscopically eradicated for polyps in 3 (1\u20134) sessions with sustenance of laboratory parameters at 1 year and 30% symptomatic recurrence at follow-up of 23.5 (7\u201340) months. There were no major endoscopic complications. Nineteen patients required proctocolectomy with improvement in laboratory parameters 6 months post-surgery. <b><i>Conclusions:<\/i><\/b> Multiple polyps behave similar to single polyps in children. A clinico-endoscopic criterion may guide for optimal management of polyposis syndrome. Colectomy may be effectively deferred in a large proportion of polyposis syndrome patients if maintained on an endoscopic protocol. <\/jats:p>","DOI":"10.1159\/000508866","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T21:00:38Z","timestamp":1590440438000},"page":"25-32","source":"Crossref","is-referenced-by-count":11,"title":["Gastrointestinal Polyps and Polyposis in Children: Experience of Endoscopic and Surgical Outcomes"],"prefix":"10.1159","volume":"39","author":[{"given":"Parijat Ram","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moinak","family":"Sen Sarma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surender Kumar","family":"Yachha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Lal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshu","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujjal","family":"Poddar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.176_b.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1972-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000634"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000002246"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.326"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/0009922811407177"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032015000400010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90885-g"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03860.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181956e0c"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000002248"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000002247"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:57Z","timestamp":1745424897000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000508866","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]}}}