{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:54:25Z","timestamp":1792803265593,"version":"4.5.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Characteristic changes in cerebral saturation (CrSO<sub>2<\/sub>), amplitude-integrated electroencephalography (aEEG), and echocardiography (ECHO) may be associated with intraventricular hemorrhage (IVH); however, the feasibility of their combined application is not known. <b><i>Objective:<\/i><\/b> The aim of this work was to investigate the feasibility and safety of combined multimodal cerebral and hemodynamic monitoring in extremely low gestational age (ELGA) infants in the first 72 h after birth. <b><i>Methods:<\/i><\/b> In this prospective \u00adobservational study of 50 infants born between 23 + 0 and 27 + 6 weeks gestation, we measured CrSO<sub>2<\/sub> and aEEG, starting &#x3c;8 h until 72 h of age. Sequential echocardiography and head ultrasound were performed at 4\u20138, 12\u201318, 24\u201330, and 48\u201360 h of age. The primary outcome was feasibility of multimodal monitoring, defined as &#x3e;75% of the subjects satisfying at least 3\/4 criteria: (a) CrSO<sub>2<\/sub> and (b) aEEG monitoring each for &#x3e;75% of the time, and (c) at least 2 out of 4 ECHO and (d) head ultrasounds (at least one by age 24 h). Adverse reactions to sensors, desaturation, and bradycardia during ultrasound studies were recorded. <b><i>Results:<\/i><\/b> Fifty infants were enrolled over 14 months. Multimodal monitoring was feasible in 49 (98%) infants. Forty-one (82%) infants fulfilled all 4 criteria. Mild erythema below CrSO<sub>2<\/sub> sensors lasting 3\u20138 h without skin breakdown was noted in 8\/50 subjects (16%). Desaturation was noted during 17\/197 (8.6%) of the ultrasound studies. In total, 26\/50 (52%) infants developed IVH (grade I\/II, <i>n<\/i> = 22; grade III\/IV, <i>n<\/i> = 4). <b><i>Conclusion:<\/i><\/b> Multimodal monitoring is feasible, safe, and well tolerated in ELGA infants in the first 72 h after birth. <\/jats:p>","DOI":"10.1159\/000508961","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T21:00:46Z","timestamp":1597870846000},"page":"504-512","source":"Crossref","is-referenced-by-count":18,"title":["Combined Multimodal Cerebral Monitoring and Focused Hemodynamic Assessment in the First 72 h in Extremely Low Gestational Age Infants"],"prefix":"10.1159","volume":"117","author":[{"given":"Poorva","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ibarra\u00a0R\u00edos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soume","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dirks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Baczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u00a0P.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecil","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick\u00a0J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-0488","authenticated-orcid":false,"given":"Prakesh","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie\u00a0","family":"Guerguerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.3.F188"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.597229"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.09.038"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.09.045"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307590"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70074-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013444"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2003.159"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2011.05.015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.71"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.127"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.08.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.134674"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.186"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181c1b176"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181d4ecda"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.11.018"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.02.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000345202"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.139"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14975"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.3243"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0780"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.017"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306483"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.266"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/508961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:42:00Z","timestamp":1745422920000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000508961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,2]]},"published-print":{"date-parts":[[2020,12,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000508961","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12826391","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}