{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:17:38Z","timestamp":1790839058922,"version":"4.1.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objectives:<\/i><\/b> To determine differences in body composition and glucose metabolism according to childhood growth outcomes in a population-based sample of children born small for gestational age (SGA). <b><i>Methods:<\/i><\/b> A single-centre study of 259 children born SGA identified through hospital records and contacted when aged 4\u20137 years. Questionnaire data on pre\/perinatal history and growth parameters during childhood was collected from the parents, and in a subgroup of 150 children face-to-face assessments were performed, including anthropometric parameters, lean and fat mass, blood pressure, fasting glucose, and C-peptide. <b><i>Results:<\/i><\/b> Based on the questionnaires, few children had formal clinic follow-up of growth, but 7% of the cohort showed a height and weight of &#x3c;\u20132SDS during childhood, and only 2 children met the criteria for growth hormone therapy. Out of the 150 children assessed at a mean age of 6.1 \u00b1 0.8 years, 122 (81%) showed a catch-up growth in weight. Compared to those without weight catch-up, these children had a higher fat mass index (3.13 \u00b1 1.36 vs. 2.56 \u00b1 0.91 kg\/m<sup>2<\/sup>, <i>p<\/i> = 0.04), trunk-to-limb fat mass ratio (0.63 \u00b1 0.14 vs. 0.56 \u00b1 0.08, <i>p<\/i> = 0.002), systolic blood pressure SDS (0.09 \u00b1 0.71 vs. \u20130.32 \u00b1 0.63, <i>p<\/i> = 0.008), fasting glucose (4.5 \u00b1 0.5 vs. 4.3 \u00b1 0.5 mmol\/L, <i>p<\/i> = 0.03), and C-peptide (306 \u00b1 116 vs. 256 \u00b1 112 pmol\/L, <i>p<\/i> = 0.08). Among children with weight catch-up growth, those with less height gain had a lower limb lean mass index (4.25 \u00b1 0.48 vs. 4.48 \u00b1 0.56 kg\/m<sup>2<\/sup>, <i>p<\/i> = 0.02) and fat mass index (1.57 \u00b1 0.59 vs. 1.83 \u00b1 0.77 kg\/m<sup>2<\/sup>, <i>p<\/i> = 0.04). <b><i>Conclusions:<\/i><\/b> Within this population-based sample of SGA children, catch-up growth in weight was associated with higher abdominal fat mass, blood pressure and glycemia; furthermore, in these children, less height gain was associated with reduced limb lean and fat mass. <\/jats:p>","DOI":"10.1159\/000508974","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T21:03:36Z","timestamp":1595538216000},"page":"119-127","source":"Crossref","is-referenced-by-count":20,"title":["Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the 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