{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:17Z","timestamp":1745468717614,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Eosinophilia (eosinophil fraction of leukocytes &#x3e;5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change in eosinophil count (EOC) and its association with death-censored technique failure among peritoneal dialysis (PD) patients remain unclear. <b><i>Methods:<\/i><\/b> We compared eosinophils before and after PD initiation among 1,432 eligible continuous ambulatory PD patients regularly followed up in our PD center during 2007\u20132018. Risk factors of early-stage eosinophilia were examined by the logistic regression test. The relationship of early-stage eosinophilia and EOC with death-censored technique failure was examined using the Cox proportional hazards model for overall patients and for men and women separately. <b><i>Results:<\/i><\/b> After PD initiation, the EOC and percentage of patients with eosinophilia were significantly increased compared with baseline. Being male (odds ratio [OR]: 2.26; 95% confidence interval [CI]: 1.55\u20133.31; <i>p<\/i> &#x3c; 0.001) and higher EOC at baseline (100 cells\/\u03bcL increase, OR: 1.62; 95% CI: 1.45\u20131.82; <i>p<\/i> &#x3c; 0.001) were risk factors of early-stage eosinophilia after PD initiation. During follow-up, 204 death-censored technique failures were recorded. In fully adjusted models, each with 100 cells\/\u03bcL increase in EOC, the adjusted hazard ratios (HRs) of technique failure were 1.11 (95% CI: 1.03\u20131.20; <i>p<\/i> = 0.009) in the whole cohort, 1.29 (95% CI: 1.10\u20131.51; <i>p<\/i> = 0.002) in women, and 1.07 (95% CI: 0.97\u20131.17; <i>p<\/i> = 0.196) in men. Eosinophilia was significantly associated with the risk of technique failure for women (HR: 2.24; 95% CI: 1.07\u20134.70; <i>p<\/i> = 0.033), which was especially significant for women aged &#x3c;55 years (HR: 7.61; 95% CI: 1.88\u201330.90; <i>p<\/i> = 0.005). <b><i>Conclusion:<\/i><\/b> EOC was increased significantly after PD initiation, and increased numbers of eosinophils were associated with higher death-censored technique failure in PD patients, especially women. <\/jats:p>","DOI":"10.1159\/000509085","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T21:01:05Z","timestamp":1595365265000},"page":"765-773","source":"Crossref","is-referenced-by-count":2,"title":["Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients"],"prefix":"10.1159","volume":"181","author":[{"given":"Jiayi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.181"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.08.023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft055"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000504847"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.051"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq745"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.589943"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12395"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz296"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00794.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-1-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007554.pub2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00100"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.141.9.1172"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4766"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000045266"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.6.660"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02958.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.040"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-014-0590-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01874-2019"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.08.012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02237-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.06.030"}],"container-title":["International 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