{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:08:42Z","timestamp":1778962122827,"version":"3.51.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objectives:<\/i><\/b> The goal of this study was to evaluate whether serum fibroblast growth factor 21 (FGF21) levels can be used to predict the prognosis of dilated cardiomyopathy (DCM). <b><i>Methods:<\/i><\/b> 241 patients with DCM and 80 control subjects were recruited and followed up for an average of 16.12 months. A 2-dimensional (2-D) echocardiography technique was performed to calculate the left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) percentages. The levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatinine were measured in routine clinical laboratory tests. Serum FGF21 levels were measured by enzyme-linked immunosorbent assay (ELISA). <b><i>Results:<\/i><\/b> The levels of serum FGF21 were significantly higher in the DCM groups than in the control groups (225.85 \u00b1 32.57 vs. 145.36 \u00b1 30.57, <i>p<\/i> &#x3c; 0.001). Serum FGF21 levels were positively correlated with the NYHA functional classification of heart failure (HF) (<i>r<\/i> = 0.610, <i>p<\/i> &#x3c; 0.001) and NT-proBNP levels (<i>r<\/i> = 0.741, <i>p<\/i> &#x3c; 0.001). Moreover, a negative correlation was observed between the serum FGF21 levels and the LVEF (<i>r<\/i> = \u20130.402, <i>p<\/i> &#x3c; 0.001). FGF21, NT-proBNP, the LVEF and a history of atrial fibrillation (AF) correlated significantly with NYHA class IV (<i>p<\/i> &#x3c; 0.05). The AUC of NT-proBNP for predicting NYHA class IV in DCM patients was greater than that of FGF21 (0.830 vs. 0.772, <i>p<\/i> &#x3c; 0.001). Overall, 133 patients with DCM were recorded at the end point. Kaplan-Meier analysis results showed that the survival probability of those individuals with high levels of FGF21 and NT-proBNP was significantly lower than of those with low levels of these factors (<i>p<\/i> &#x3c; 0.001). In the multivariate Cox analysis, FGF21 (HR 2.561; 95% CI 1.705\u20133.849) and NT-proBNP (HR 4.458; 95% CI 2.645\u20137.513) were independent predictors of a poor prognosis in DCM patients. <b><i>Conclusions:<\/i><\/b> Serum FGF21 levels were associated with the risk factors, severity, and prognosis of DCM. Therefore, FGF21 may serve as a novel biomarker for the prognosis of DCM. <\/jats:p>","DOI":"10.1159\/000509239","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:00:38Z","timestamp":1606946438000},"page":"27-33","source":"Crossref","is-referenced-by-count":24,"title":["Fibroblast Growth Factor 21 Correlates with the Prognosis of Dilated Cardiomyopathy"],"prefix":"10.1159","volume":"146","author":[{"given":"Lingyun","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruolong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genshan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-16-0037"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.590"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115146"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.5.8477647"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2017.02.015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.12.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.08.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12095"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0142"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu263"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2308"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.11.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.11.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000486127"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0588-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129791"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30744-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.01.017"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1540267"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00419"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.05.007"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09809-x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020233"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13976-1"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.04.010"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3458-7"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:44:59Z","timestamp":1745423099000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,2]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000509239","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,2]]}}}