{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:27:38Z","timestamp":1782527258233,"version":"3.54.5"},"reference-count":28,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To report the experience with prenatal repair of open spina bifida (OSB) from 2 centers in Chile. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Women with a second-trimester fetus with OSB were offered intrauterine neurosurgical repair following the protocol from the Management of Myelomeningocele Study (MOMS) trial. Pediatric follow-up with infants reaching 12 and 30 months of life was also reviewed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Fifty-eight fetuses with OSB underwent intrauterine repair at an average (\u00b1SD) gestational age of 24.8 \u00b1 0.9 weeks. There were 3 (5.1%) intrauterine deaths. The average gestational age at delivery of the remaining 55 cases was 33.3 \u00b1 3.6 weeks, and the average birth weight was 2,172 \u00b1 751 g. Delivery before 30 weeks occurred in 11 cases (20.0%). Two (3.6%) neonatal deaths (&amp;#x3c;28 days) occurred. At 12 months, a ventriculoperitoneal shunt or an endoscopic third ventriculostomy was required in 25% of the cases. At 30 months, 72.4% of the infants were able to walk. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; Prenatal neurosurgical repair of OSB is a complex and challenging intervention. Major complications include perinatal death and severe prematurity. No major maternal complications occurred in our series. A reduction in the need for cerebrospinal fluid diversion and an improved ability to walk seem to be the greatest long-term advantages of this procedure. <\/jats:p>","DOI":"10.1159\/000509242","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:00:28Z","timestamp":1600290028000},"page":"873-881","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal Repair of Spina Bifida: A 2-Center Experience with Open Intrauterine Neurosurgery in Chile"],"prefix":"10.1159","volume":"47","author":[{"given":"Waldo","family":"Sepulveda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan L.","family":"Alcalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Otayza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Ravera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Devoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5383"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000449382"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1566902"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3445-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.964"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3437-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4573"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000438508"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000478261"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.09.043"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000494024"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5421"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000365353"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000089060"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1819"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000067560"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.PEDS15336"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(99)70167-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000089301"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13430"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.065"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14673"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20389"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001941"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15830"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000443498"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000479505"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:02Z","timestamp":1745423102000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,17]]},"published-print":{"date-parts":[[2020,12,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000509242","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}