{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:23Z","timestamp":1745468723011,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To report a case with rapid regression of scleral melting associated with tumor necrosis factor-\u03b1 (TNF-\u03b1) in a surgically induced necrotizing scleritis (SINS) patient treated with local steroid therapy. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; An 85-year-old male patient presented with conjunctival tumor in his right eye. Complete resection of the tumor lesion and conjunctival re-construction were performed. Local steroid drops were administered until 1 month after surgery, and a good clinical course was achieved. However, after stopping the local steroid, scleral melting to the uvea occurred on the center of the tumor-resected sclera. After diagnosing SINS, we immediately restarted his local steroid. After 2 weeks, there was a complete and rapid regression of the scleral melting. Following this episode, only local steroid therapy was continued for the treatment of SINS, with no recurrence observed after 6 months. Histopathological analysis revealed the infiltration of inflammatory cells during the acute phase, with TNF-\u03b1 immune reactivity observed in the center of the melting site near the resected conjunctiva. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We speculate that the observed changes were associated with the TNF-\u03b1 that was present during the pathological state of SINS. Local steroid therapy may play a key role in the local immune balance in SINS. <\/jats:p>","DOI":"10.1159\/000509260","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T21:01:28Z","timestamp":1596747688000},"page":"418-422","source":"Crossref","is-referenced-by-count":2,"title":["Rapid Regression of Scleral Melting Associated with Tumor Necrosis Factor-\u03b1 in a Case of Surgically Induced Necrotizing Scleritis"],"prefix":"10.1159","volume":"11","author":[{"given":"Norihiko","family":"Misawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32062-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S24885"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.1.17"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200204000-00013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000090010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001044"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-325225"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:15Z","timestamp":1745423115000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,9,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000509260","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}