{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:17:19Z","timestamp":1789708639437,"version":"4.0.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Endobronchial ultrasound elastography that provides information on tissue stiffness may help distinguish malignant from benign mediastinal and hilar lymph nodes. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; In this prospective trial, we assessed the diagnostic value of elastographic images and the interobserver agreement in its evaluation. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; Elastographic images from 77 lymph nodes in 65 patients were reviewed by 3 pneumologists. The elastographic image was classified based on the predominant colour: predominantly green, intermediary, and predominantly blue. With 2 or 3 interobserver matches, the corresponding elastographic image was correlated with the pathological result obtained from endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and\/or other invasive procedures. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All 3 reviewers had agreement in classifying elastographic images in 45% (35\/77). Overall, the interobserver agreement among the 3 readers for classifying elastographic pattern was found to be moderate (Fleiss Kappa index = 0.519; 95% CI = [0.427; 0.611]). On cytological\/histological evaluation, 55 lymph nodes were malignant and 22 were benign. In classifying \u201cgreen\u201d as benign and \u201cblue\u201d as malignant, the sensitivity and specificity were 71% (95% CI = [54%; 85%]) and 67% (95%-CI = [35%; 90%]), respectively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Elastography will not replace invasive EBUS-TBNA due to a moderate interobserver agreement and insufficient sensitivity and specificity. However, elastography will, maybe, present an additional feature to identify malignant lymph nodes in the context of clinical, radiological, and cytological results. <\/jats:p>","DOI":"10.1159\/000509297","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T21:01:15Z","timestamp":1602104475000},"page":"779-783","source":"Crossref","is-referenced-by-count":13,"title":["Endobronchial Ultrasound Elastography for Differentiating Benign and Malignant Lymph Nodes"],"prefix":"10.1159","volume":"99","author":[{"given":"Daniela","family":"Gompelmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Kontogianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilab","family":"Sarmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philine","family":"Kaukel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Krisam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-2506","authenticated-orcid":false,"given":"Felix J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1392040"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70407-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.05.110"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu105"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/raon-2015-0020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000441798"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19031"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000464253"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7150\/jca.19819"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12979"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000494143"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13186"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:41Z","timestamp":1745423141000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,12,8]]},"published-print":{"date-parts":[[2020,12,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000509297","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}