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Such a vaccine should efficiently induce high-affinity neutralizing antibodies which neutralize SARS-CoV-2, the cause of COVID-19. However, there is a concern regarding both vaccine-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology. <\/jats:p>","DOI":"10.1159\/000509368","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T21:00:39Z","timestamp":1592341239000},"page":"624-628","source":"Crossref","is-referenced-by-count":22,"title":["Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection"],"prefix":"10.1159","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-7736","authenticated-orcid":false,"given":"Hans-Uwe","family":"Simon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-5424","authenticated-orcid":false,"given":"Alexander\u00a0V.","family":"Karaulov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin\u00a0F.","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001899"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2020.58"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2005630"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000504847"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1855"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/515322"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13196"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035421"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030525"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06791-11"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-017-0074-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8020153"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01774.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/08820131003663357"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.03.026"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-017-0030-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.174"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.811208"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.966085"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2415"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06048-11"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.126"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409065102"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.10.046"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:46:31Z","timestamp":1745423191000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,5]]},"published-print":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000509368","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2020]]}}}