{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:47:46Z","timestamp":1767833266309,"version":"3.49.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Umbilical cord occlusion via radiofrequency ablation (RFA) is utilized to maximize outcomes of the co-twin in complicated multifetal monochorionic (MC) gestations. However, post-procedure co-twin fetal demise is of concern. <b><i>Objective:<\/i><\/b> The aim of this study was to determine risk factors for co-twin fetal demise following RFA. <b><i>Methods:<\/i><\/b> This is a retrospective study of MC multiples that underwent RFA. Indications for RFA included twin reversed arterial perfusion (TRAP) sequence, selective fetal growth restriction (sFGR) type II, discordant lethal anomalies, and twin-twin transfusion syndrome (TTTS) with proximate placental cord insertion sites. The primary outcome was co-twin fetal demise. Bivariate analyses and multiple logistic regression modeling of identified risk factors were conducted. <b><i>Results:<\/i><\/b> Of 36 patients studied, surgical indications were: TRAP (<i>n<\/i> = 15, 41.7%), sFGR (<i>n<\/i> = 10, 27.8%), discordant anomalies (<i>n<\/i> = 9, 25.0%), and TTTS (<i>n<\/i> = 2, 5.6%). Nine patients (25.0%) experienced a co-twin fetal demise. In multiple logistic regression analysis, fetal growth restriction (FGR) of one co-twin was associated with increased risk of co-twin fetal demise (OR = 10.85, 95% CI 1.03\u2013114.48, <i>p<\/i> = 0.0474) and a preoperative diagnosis of TRAP was protective against fetal demise (OR = 0.06, 95% CI 0.00\u20130.84, <i>p<\/i> = 0.0368). <b><i>Conclusion:<\/i><\/b> Co-twin FGR was associated with an increased risk of post-RFA demise. When compared to other indications, patients with TRAP sequence were less likely to have a co-twin demise. <\/jats:p>","DOI":"10.1159\/000509401","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T21:01:13Z","timestamp":1596834073000},"page":"817-823","source":"Crossref","is-referenced-by-count":10,"title":["Risk Factors for Co-Twin Fetal Demise following Radiofrequency Ablation in Multifetal Monochorionic Gestations"],"prefix":"10.1159","volume":"47","author":[{"given":"Lauryn C.","family":"Gabby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Chon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Korst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlyn","family":"Llanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramen H.","family":"Chmait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.08.033"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.07.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2536"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15933"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.046"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20114"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01027.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822f129d"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000500774"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.039"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.04.035"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000445291"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11122"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.10.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.11.039"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.051"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.12.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000448948"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5196"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.10.195"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4046"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02624.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5269"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.09.025"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1067\/s0002-9378(03)00644-6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(98)70086-9"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1993.tb01630.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199804000-00018"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120486"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:46:44Z","timestamp":1745423204000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,10,22]]},"published-print":{"date-parts":[[2020,10,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000509401","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}