{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:47:55Z","timestamp":1792277275769,"version":"4.4.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>The effect of PD-1 blockade as a first-line therapy in nonmetastatic head and neck squamous cell carcinoma (HNSCC) remains unknown. We report a case of an exceptional response to PD-1 blockade as a first-line therapy in a patient with HNSCC and lung cancer. A 59-year-old man presented with cheek swelling and chest pain. He was diagnosed with maxillary sinus carcinoma (squamous cell carcinoma) and lung cancer (non-small-cell lung cancer, not otherwise specified). The maxillary sinus carcinoma was completely resolved after 8 cycles of pembrolizumab. Immune checkpoint blockade warrants further evaluation in previously untreated patients with HNSCC. <\/jats:p>","DOI":"10.1159\/000509485","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T21:00:34Z","timestamp":1599166834000},"page":"343-350","source":"Crossref","is-referenced-by-count":1,"title":["Exceptional Response to PD-1 Blockade as First-Line Therapy in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1159","volume":"82","author":[{"given":"Takumi","family":"Kumai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Komatsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Harabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31999-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.3994"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.1524"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25635"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30516-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30413-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1316"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32591-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32409-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2955"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30421-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01896"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.9929"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2641"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091317"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104525"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.1478"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2384"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1329071"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:47:22Z","timestamp":1745423242000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,27]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000509485","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}