{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:35:22Z","timestamp":1785231322176,"version":"3.55.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Infectious mononucleosis is a largely benign disease process that occurs secondary to infection with the Epstein-Barr virus. However, it can also present with more serious complications, including auto-immune hemolytic anemia and acute liver failure. Hereditary hemochromatosis is a genetic disorder that leads to organ damage via increased iron uptake and deposition. This case report describes a 25-year-old man who presented with acute liver failure and severe hemolytic anemia. Workup revealed that not only did he have a rare presentation of Epstein-Barr virus-induced acute liver failure and C&lt;sub&gt;3&lt;\/sub&gt;-positive IgG-negative hemolytic anemia, he also had previously undiagnosed hereditary hemochromatosis. This combined presentation of these pathologies presents a unique opportunity to study their interaction and possible synergistic pathophysiology. Furthermore, the evolving understanding of the disease mechanisms behind these disease processes is described. <\/jats:p>","DOI":"10.1159\/000509742","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:00:37Z","timestamp":1601499637000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":5,"title":["Infectious Mononucleosis Causing Acute Liver Failure and Hemolytic Anemia in a Patient with Underlying Hereditary Hemochromatosis"],"prefix":"10.1159","volume":"13","author":[{"given":"Mark","family":"Forsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Galan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(03)00543-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2008.1390"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000065316"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.17.2216"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25686071424.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4137\/CCRep.S11469"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-474437"},{"key":"ref8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.04.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073286"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i4.637"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nm0497-409"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02138.x"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:47Z","timestamp":1745423387000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000509742","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}